약학회지 (YAKHAK HOEJI)
- 제40권1호
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- Pages.1-9
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- 1996
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
위장관 수술환자에서 겐타마이신의 임상약물동태
Clinical Pharmacokinetics of Gentamicin in Gastrointestinal Surgical Patients
- Choi, Jun-Shik (College of Pharmacy, Chosun University) ;
- Moon, Hong-Seog (Chosun University Hospital Pharmacy) ;
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Choi, In
(Chosun University Hospital Pharmacy) ;
- Burm, Jin-Pil (College of Pharmacy, Chosun University)
- 발행 : 1996.02.01
초록
The purpose of this investigation was to determine pharmacokinetic parameters of gentamicin using nonlinear least square regression(NLSR) and Bayesian analysis in Korean normal volunteers and gastrointestinal surgical patients. Nonparametric expected maximum(NPEM) method for population pharmacokinetic parameters was used. Gentamicin was administered every 8 hours for 3 days by infusion over 30 minutes. The volume of distribution(V) and elimination rate constant(K) of gentamicin were
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