YAKHAK HOEJI (약학회지)
- Volume 40 Issue 3
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- Pages.326-334
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- 1996
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Immunobiological Studies on Doses of Methanol Extract of Astragali Radix
황기의 메탄올 추출물의 용량에 따른 면역생물학적 연구
- Kim, Joung-Hoon (Center for Food and Drug Safety, Wonkwang University) ;
- Park, Joung-Suk (Center for Food and Drug Safety, Wonkwang University) ;
- Chae, Byeong-Suk (Center for Food and Drug Safety, Wonkwang University) ;
- Kang, Tae-Wook (Center for Food and Drug Safety, Wonkwang University) ;
- Park, Chan-Bong (Center for Food and Drug Safety, Wonkwang University) ;
- Ahn, Young-Keun (Center for Food and Drug Safety, Wonkwang University)
- 김정훈 (원광대학교 식품약품안전성연구소) ;
- 박정숙 (원광대학교 식품약품안전성연구소) ;
- 채병숙 (원광대학교 식품약품안전성연구소) ;
- 강태욱 (원광대학교 식품약품안전성연구소) ;
- 박찬봉 (원광대학교 식품약품안전성연구소) ;
- 안영근 (원광대학교 식품약품안전성연구소)
- Published : 1996.06.01
Abstract
Effects of methanol extract of Astragali Radix (AR) on the immune responses were studied using ICR mice. Mice were divided into 4 groups (10mice/group), and methanol extracts of AR at doses of 0.05, 0.25 and 1.25g/kg were orally administered to ICR mice once a day for 2 weeks. Mice were immunized and challenged with sheep red blood cells (SRBC). The results of this study were summarized as follows; (1) Methanol extract of AR at 0.05, 0.25 and 1.25g/kg didn't affect the weight ratios of thymus to body, as compared with those in controls, but significantly increased spleen weight ratio. (2)Methanol extract of AR at 0.05 and 0.25g/kg significantly increased hemagglutination titer and splenic plaque forming cells corresponding to humoral immunity, as compared with those in controls, but their enhancements were somewhat lowered at a high dose (1.25g/kg). (3) Methanol extract of AR at 0.05 and 0.25g/kg siginificantly increased delayed-type hypersensitivity reaction resulted from cell-mediated immunity, as compared with those in controls, but not so significant increases were observed at a high dose (1.25g/kg). (4) Methanol extract of AR at 0.05 and 0.25g/kg significantly increased phagocytic activity and the number of circulating leukocyte compared with those in controls, but their enhancements were lowered at a high dose (1.25g/kg). These results suggest that methanol extract of Astragali Radix increased humoral and cell-mediated immune responses, phagocytic activity and the number of circulating leukocyte, dependent upon dose, but inhibited their enhancement effects were decreased at a high dose (1.25g/kg).