약학회지 (YAKHAK HOEJI)
- 제40권4호
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- Pages.462-467
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- 1996
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
L1210 및 HL60 Cell에 대한 연교의 세포독성 성분
Cytotoxic Constituents from the Forsythiae Fructus against L1210 and HL60 cells
- Lee, Jun-Seong (College of Pharmacy, Chungnam National Univ.) ;
- Min, Byeong-Seon (College of Pharmacy, Chungnam National Univ.) ;
- Bae, Gi-Hwan (College of Pharmacy, Chungnam National Univ.)
- 발행 : 1996.08.01
초록
Forsythiae Fructus was studied on cytotoxic activities for the purpose of finding out active consituents against L1210 and HL60 cells. To isolate the active ones, the methanolic extract was partitioned into water insoluble and water soluble fractions. Furthermore, the water soluble fraction was fractionated into four parts, n-hexane, benzene, ethylacetate and water fractions. Among these, the water insoluble fraction showed the most potent cytotoxic activities on L1210 and HL60 cells in vitro. The water insoluble fraction was applied to silica gel column chromatography and divided into 5 fractions(fr. 1-5). The active constituents I and II were isolated from fr.2 and 3, respectively, by repeated silica gel column chromatography and recrystallization. The constituents were identified as 3
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