약학회지 (YAKHAK HOEJI)
- 제40권4호
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- Pages.428-437
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- 1996
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
C7-이환체 구조를 갖는 새로운 플루오르퀴놀론계 항생제의 in vitro와 in vivo 항균작용
In vitro and In vivo Antibacterial Activity of a New Fluoroquinolone Containing C7-bicyclic Structure
-
한승희
((주) 대웅제약 중앙연구소) ;
- 최문정 ((주) 대웅제약 중앙연구소) ;
- 김지연 ((주) 대웅제약 중앙연구소) ;
- 김병오 ((주) 대웅제약 중앙연구소) ;
- 심점순 ((주) 대웅제약 중앙연구소) ;
- 강진석 ((주) 대웅제약 중앙연구소) ;
- 손호정 ((주) 대웅제약 중앙연구소) ;
- 이재욱 ((주) 대웅제약 중앙연구소) ;
-
유영효
((주) 대웅제약 중앙연구소) ;
- 박명환 ((주) 대웅제약 중앙연구소)
-
Han, Seung-Hui
(R & D center, Daewoong Pharmaceutical Co., Ltd.) ;
- Choe, Mun-Jeong (R & D center, Daewoong Pharmaceutical Co., Ltd.) ;
- Kim, Ji-Yeon (R & D center, Daewoong Pharmaceutical Co., Ltd.) ;
- Kim, Byeong-O (R & D center, Daewoong Pharmaceutical Co., Ltd.) ;
- Sim, Jeom-Sun (R & D center, Daewoong Pharmaceutical Co., Ltd.) ;
- Gang, Jin-Seok (R & D center, Daewoong Pharmaceutical Co., Ltd.) ;
- Son, Ho-Jeong (R & D center, Daewoong Pharmaceutical Co., Ltd.) ;
- Lee, Jae-Uk (R & D center, Daewoong Pharmaceutical Co., Ltd.) ;
-
Yu, Yeong-Hyo
(R & D center, Daewoong Pharmaceutical Co., Ltd.) ;
- Park, Myeong-Hwan (R & D center, Daewoong Pharmaceutical Co., Ltd.)
- 발행 : 1996.08.01
초록
The in vitro and in vivo antibacterial activities of a new fluoroquinolone, DWP20364(1-cyclopropyl-5-amino-6,8-difluoro-7-(2,7-diazabicyclo[3.3.0]oto-4-ene-7-yl)-1 ,4-di-hydro-4-oxoquinoline-3-carboxylic acid) were evaluated in comparison with those of ciprofloxacin(CPFX), sparfloxacin(SPFX) and ofloxacin(OFLX). DWP20364 was more potent than CPFX and OFLX against Staphylococcus spp., Streptococcus spp. and Enterococcus faecium MD8b and it was similarly or slightly less active than CPFX against Escherichia spp. and Pseudomonas spp.. For MRSA and OFLX resistant strains (Staphylococcus spp.(14),Enterococcus spp.(4), Acinetobacter spp.(2), Pseudomonas spp.(9), Klebsiella spp.(2) and Serratia spp.(6)),DWP20364(MICs for 90% of strains,0.025 and 12.5