약학회지 (YAKHAK HOEJI)
- 제40권2호
- /
- Pages.131-134
- /
- 1996
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
크실로피닌의 합성
Synthesis of Xylopinine
- Hwang, Soon-Ho (College of Pharmacy, Kyung Hee University) ;
-
Kim, Nam-Jae
(College of Pharmacy, Kyung Hee University)
;
- Hong, You-Hwa (College of Pharmacy, Kyung Hee University) ;
- Kim, In-Jong (College of Pharmacy, Kyung Hee University) ;
- Kim, Sin-Kyu (College of Pharmacy, Kyung Hee University)
- 발행 : 1996.04.01
초록
3,4-Dimethoxyphenethyl amine(1) and 3,4-dimethoxybenzaldehyde were converted to compounds(4) through sucessive condensation and reduction reaction. Compound(4) was treated with methylthioacetyl chloride to give compound(5) then m-chloroperbenzoic acid(m-CPBA) treatment of compound(5) produced S-oxide(6). To obtain isoquinoline derivative(7),(8), compound(6) were treated with p-TsOH. Xylopinine(9) and it's derivatives(10) were produced by Bischler-Napieralski reaction.