YAKHAK HOEJI (약학회지)
- Volume 40 Issue 2
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- Pages.131-134
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- 1996
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Synthesis of Xylopinine
크실로피닌의 합성
- Hwang, Soon-Ho (College of Pharmacy, Kyung Hee University) ;
-
Kim, Nam-Jae
(College of Pharmacy, Kyung Hee University)
;
- Hong, You-Hwa (College of Pharmacy, Kyung Hee University) ;
- Kim, In-Jong (College of Pharmacy, Kyung Hee University) ;
- Kim, Sin-Kyu (College of Pharmacy, Kyung Hee University)
- Published : 1996.04.01
Abstract
3,4-Dimethoxyphenethyl amine(1) and 3,4-dimethoxybenzaldehyde were converted to compounds(4) through sucessive condensation and reduction reaction. Compound(4) was treated with methylthioacetyl chloride to give compound(5) then m-chloroperbenzoic acid(m-CPBA) treatment of compound(5) produced S-oxide(6). To obtain isoquinoline derivative(7),(8), compound(6) were treated with p-TsOH. Xylopinine(9) and it's derivatives(10) were produced by Bischler-Napieralski reaction.
Keywords