한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제24권1호
  • /
  • Pages.77-81
  • /
  • 1996
  • /
  • 1598-642X(pISSN)
  • /
  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

Streptomyces sp. 3D3 균주가 생산하는 항고추역병성 항생물질

An Antifungal Compound Against Phytophthora capsici Produced by Streptomyces sp. 3D3

  • 윤봉식 (한국과학기술연구원 생명공학연구소) ;
  • 김창진 (한국과학기술연구원 생명공학연구소) ;
  • 이인경 (한국과학기술연구원 생명공학연구소) ;
  • 히로유끼 고시노 (이화학연구소, 일본) ;
  • 유익동 (한국과학기술연구원 생명공학연구소)
  • Yun, Bong-Sik (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Kim, Chang-Jin (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Lee, In-Kyoung (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Hiroyuki, Koshino (The Institute of Physical and Chemical Research (RIKEN)) ;
  • Yoo, Ick-Dong (Korea Research Institute of Bioscience and Biotechnology, KIST)
  • 발행 : 1996.02.01
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초록

During the screening for the antifungal compounds against Phytophthora capsici causing phytophthora blight of red pepper, we isolated a strong active compound, bafilomycin $C_1$, produced by strain 3D3. The producing organism was identified as Streptomyces sp. based on taxonomic studies. The antifungal compound was purified from culture broth by HP-20 column chromatography, ethylacetate extraction, silica gel column chromatography and HPLC, and was identified as bafilomycin $C_1$ by color reaction, UV and $^{1}H$-NMR spectral data analysis. Bafilomycin $C_1$ showed strong antifungal activity against various phytopathogenic fungi.

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