The Korean Journal of Nuclear Medicine (대한핵의학회지)
- Volume 30 Issue 3
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- Pages.344-350
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- 1996
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- 1225-6714(pISSN)
Imaging of Tumor Proliferation Using Iodine-131-Iodomethyluridine
Iodine-131-Iodomethyluridine을 이용한 종양세포증식의 영상화에 관한 실험적 연구
- Min Kyung-Yoon (Department of Radiology, Wonkwang University School of Medicine) ;
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Kim, Chang-Guhn
(Department of Radiology, Wonkwang University School of Medicine) ;
- Kim, Hyun-Jeong (Department of Radiology, Wonkwang University School of Medicine) ;
- Lim, Hyung-Guhn (Department of Radiology, Wonkwang University School of Medicine) ;
- Rho, Ji-Young (Department of Radiology, Wonkwang University School of Medicine) ;
- Juhng Seon-Kwan (Department of Radiology, Wonkwang University School of Medicine) ;
- Won Jong-Jin (Department of Radiology, Wonkwang University School of Medicine) ;
- Yang, David J. (University of Texas, MD Anderson Cancer Center)
- 민경윤 (원광대학교 의과대학 방사선과학교실) ;
-
김창근
(원광대학교 의과대학 방사선과학교실) ;
- 김현정 (원광대학교 의과대학 방사선과학교실) ;
- 임형근 (원광대학교 의과대학 방사선과학교실) ;
- 노지영 (원광대학교 의과대학 방사선과학교실) ;
- 정선관 (원광대학교 의과대학 방사선과학교실) ;
- 원종진 (원광대학교 의과대학 방사선과학교실) ;
- 양경문
- Published : 1996.10.20
Abstract
Purpose : Noninvasive imaging of tumor cell proliferation could be helpful in the evaluation of tumor growth potential and could provide an early assessment of treatment response. Radiolabeled thymidine, uridine and adenosine have been used to evaluate tumor cell proliferation. These nucleoside analogs are incorporated into DNA during proliferation. Iodine-131-Iodomethyluridine, an analog of Iodine-131-Iododeoxyuridine, is also involved in DNA/RNA synthesis. The purpose of this study was to develop Iodine-131-Iodomethylurdine and image tumor proliferation using Iodine-131-Iodomethyluridine. Materials and Methods : Radiosynthesis of Iodine-131-5-Iodo-2'-O-methyluridine (Iodine-131-Iodomethyluridine) was prepared from 10 mg of 2'-O-methyluridine(Sigma chemical Co., St. Louis, Missouri) and 2.1 mCi(SP. 10Ci/mg) of Iodine-131-labeled sodium iodide in
Iododeoxyuridine의 유사체인 Iodine-131-5-Iodo-2'-O-methyluridine을 합성하여 종양세포의 증식을 영상화하고자 하였다. 2'-O-methyluridine을 이용하여 Iodine-131-Iodomethyluridine을 요오드발생 반응(Iodogen reaction)으로 간편하게 합성하였고 이를 이용한 자가방사영상과 핵의학영상에서 종양세포의 증식을 영상화 할 수 있었다. 이상의 결과는 Iodine-131-Iodomethyluridine을 이용하여 종양세포의 증식을 감마카메라로 영상화하여 세포증식이 활발한 생존 종양조직이나 재발을 평가할 수 있는 가능성이 있음을 시사한다.
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