Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Lithium Trimethylalkynylaluminate, A New Chemoselective Alkynylating Agent

  • Published : 1996.04.20
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Abstract

Lithium trimethylalkynylaluminates, prepared conveniently by reacting trimethylaluminum with lithium alkynide, readily react with aldehydes and ketones to give the corresponding propargyl alcohols in 70-95% yields. The reaction is highly chemoselective; thus many other functional groups such as amides, nitriles, epoxides and halogen compounds are inert under the reaction conditions. The reagents also show an excellent 1,2-regiospecificity in the reactions with cyclic or acyclic α,β-unsaturated carbonyl compounds.

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References

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