Journal of Microbiology and Biotechnology
- 제6권5호
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- Pages.366-367
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- 1996
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- 1017-7825(pISSN)
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- 1738-8872(eISSN)
Inhibition Mode of DNA Topoisomerase by Dibutyl Phthalate
- Lee, Dong-Sun (Department of Microbiology, College of Natural Science, Kyungpook National University) ;
- Hong, Soon-Duck (Department of Microbiology, College of Natural Science, Kyungpook National University)
- 발행 : 1996.10.01
초록
Dibutyl phthalate induced topoisomerase Ⅰ mediated DNA relaxation comparable to that of camptothecin, and topoisomerase Ⅱ mediated DNA relaxation equipotent to that of 4'-(9-acridinylamino) methanesulfon-m-anisidide (m-AMSA). The relaxation activities of dibutyl phthalate were dose-de-pendent and nearly as potent as those of camptothecin and m-AMSA.