Journal of Microbiology and Biotechnology
- Volume 6 Issue 4
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- Pages.250-254
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- 1996
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- 1017-7825(pISSN)
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- 1738-8872(eISSN)
The Slow and Tight Binding of MR-387A to Aminopeptidase N
- CHUNG, MYUNG-CHUL (Enzyme Inhibitor Research Unit, Korea Research Institute of Bioscience and Biotechnology, KIST) ;
- HYO-KON CHUN (Enzyme Inhibitor Research Unit, Korea Research Institute of Bioscience and Biotechnology, KIST) ;
- HO-JAE LEE (Enzyme Inhibitor Research Unit, Korea Research Institute of Bioscience and Biotechnology, KIST) ;
- CHOONG-HWAN LEE (Enzyme Inhibitor Research Unit, Korea Research Institute of Bioscience and Biotechnology, KIST) ;
- SU-IL KIM (Department of Agricultural Chemistry, Seoul National University) ;
- YUNG-HEE KHO (Enzyme Inhibitor Research Unit, Korea Research Institute of Bioscience and Biotechnology, KIST)
- Published : 1996.08.01
Abstract
MR-387A [(2S, 3R)-2-hydroxy-3-amino-4-phenylbutanoyl-L-valyl-L-prolyl-(2, 4-trans)- L-4-hydroxy-proline] reversibly inhibits aminopeptidase N (BC 3.4.11.2) in a process that is remarkable for its unusual degree of time dependence. The time required to inactivate the enzyme by 50