Conformation이 고정된 Sulfonylurea 유도체의 혈당상승작용

Hyperglycemic Effect of Conformationally Rigid Sulfonylurea Derivatives

  • 박혜영 (이화여자대학교 약학대학) ;
  • 김연경 (이화여자대학교 약학대학) ;
  • 권진숙 (이화여자대학교 약학대학) ;
  • 김화정 (이화여자대학교 약학대학)
  • 발행 : 1996.12.01


3, 4-Dihydro-3-oxo-2H-1, 2, 4-benzothiadiazine-1, 1-dioxides were synthesized as conformationally rigid analogues of sulfonylurea hypoglycemic agents. All the compounds prepared showed hyperglycemic activity. The hyperglycemic activity was enhanced for the diabetic rats in which the blood glucose level was increased by 30-70%.