Biomolecules & Therapeutics

  • 제4권4호
  • /
  • Pages.314-322
  • /
  • 1996
  • /
  • 1976-9148(pISSN)
  • /
  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
권호 표지

랫드에 대한 KDRD-010의 아급성경구독성시험

Subacute Oral Toxicity of KDRD-010 in Rats

  • 곽승준 (성균관대학교 약학대학 독성학교실) ;
  • 김형식 (성균관대학교 약학대학 독성학교실) ;
  • 임소영 (성균관대학교 약학대학 독성학교실) ;
  • 천선아 (성균관대학교 약학대학 독성학교실) ;
  • 박현선 (성균관대학교 약학대학 독성학교실) ;
  • 홍채영 (성균관대학교 약학대학 독성학교실) ;
  • 한하수 (성균관대학교 약학대학 독성학교실) ;
  • 최병천 (광동제약 중앙연구소) ;
  • 이병무 (성균관대학교 약학대학 독성학교실)
  • 발행 : 1996.12.01
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초록

The subacute toxicity was investigated in Sprague-Dawley rats orally treated with KDRD-010 at the doses of 0.056, 0.28, and 1.4 g/kg for one month. There were no clinical signs and pathological changes compared with control group. Body weights were not significantly changed between control and treatment groups. In hematological and biochemical serum parameters, all mean values appear to be within the normal range. In pathological examinations, hemorrhages of lung was observed in one male rat at low dose group and one female rat at high dose group of KDRD-010, but it was not considered to be caused by KDRD-010. These results suggest that KDRD-010 dose not induce any significant subacute oral toxicities in Sprague-Dawley rats.

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