Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Effect of G009 on Lipid Peroxidation Induced by Peroxidizer in Rats

G009가 Peroxidizers에 의해 유발된 지질 과산화에 미치는 영향

  • Lee, June-Woo (Biotechnology Lab., Il Yang Pharmaceutical Co., Ltd.) ;
  • Jeong, Hoon (Biotechnology Lab., Il Yang Pharmaceutical Co., Ltd.) ;
  • Lee, Seung-Mok (Pharmacological and Toxicological Lab. Il Yang Pharmaceutical Co., Ltd.) ;
  • Kim, Ki-Nam (Biotechnology Lab., Il Yang Pharmaceutical Co., Ltd.) ;
  • Han, Man-Douk (Biotechnology Lab., Il Yang Pharmaceutical Co., Ltd.) ;
  • Lee, Seung-Yong (Biotechnology Lab., Il Yang Pharmaceutical Co., Ltd.) ;
  • Kim, Su-Ung (Biotechnology Lab., Il Yang Pharmaceutical Co., Ltd.) ;
  • Kang, Sang-Mo (Department of Microbiological Engineering, College of Engineering, Konkuk University)
  • 이준우 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 정훈 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 이승목 (일양약품(주) 중앙연구소 약리독성실) ;
  • 김기남 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 한만덕 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 이승룡 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 김수웅 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 강상모 (건국대학교 공과대학 미생물공학과)
  • Published : 1996.09.01
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Abstract

In this study, the anti-lipidperoxidative effects of G009, a polysaccharide extracted from Ganoderma lucidum IY009, was determined in ascorbic acid-$Fe^{2+}$-adenosine 5-diphosphate-intoxicated rat. In a model of ascorbic acid-Fe$^{2+}$-adenosine 5-diphosphate-induced hepatotoxicity in rat, G009 exhibited anti-lipidperoxidative effect in rat liver homogenate, and that malondialdehyde values of the liver homogenate inhibited from 48.1% to 74.8% in comparison to controls (p<0.05). The malondialdehyde formation in serum inhibited 66.5% at 100 mg/kg of G009. Also, serum levels of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase in peroxidizer-induced rats treated with G009 was decreased compared with control. Especially, the formation of lipid peroxides in serum was related to glutamic pyruvic transaminase levels. These results suggest that G009 has a protective effect on ascorbic acid-$Fe^{2+}$-adenosine 5-diphosphate-induced hepatic injury through an inhibition of lipid peroxidation in liver.r.

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