General Pharmacology of Artemisia Extract Powder, DA-9601

애엽 추출분획, DA-9601의 일반 약리작용

  • 이은방 (서울대학교 천연물과학연구소) ;
  • 천선아 (서울대학교 천연물과학연구소) ;
  • 이은심 (서울대학교 천연물과학연구소) ;
  • 김옥경 (서울대학교 천연물과학연구소) ;
  • 고석태 (조선대학교 약학대학) ;
  • 유강준 (조선대학교 약학대학) ;
  • 신동숙 (조선대학교 약학대학) ;
  • 강선영 (조선대학교 약학대학) ;
  • 김순회 (동아제약(주)연구소)
  • Published : 1996.06.01

Abstract

The general pharmacological properties of Artemisia extract powder (DA-9601) produced from Artemisia asiatica leaves were investigated in mice, rats, guinea pigs and rabbits. DA-9601 at the dose of 800 mg/kg po had no influences on general behaviour, barbital sleeping time and motor coordination of mice. The material at the oral dose of 800 mg/kg did exhibit neither analgesic action nor hypothermic effect. Anticonvulsant action, muscle relaxant action and the effect on intestinal propulsion were not identified at 800 mg/kg po. In the isolated ileum and trachea of guinea pig, the material did not show direct erect and inhibitory action of chemically or electrically stimulated contraction at the concentration of $2\times10^{-5}$g/ml. The sinus rates of atria and contractility of papillary muscle of guinea pig were not influenced by DA-9601 at a dose of $2\times10^{-5}$g/ml. No influences on blood pressure and respiration were observed at 40 mg/kg iv, in rabbits. However, transient decreases in blood pressure of rabbits were observed as given 120 mg/kg in iv route with slight respiratory depression, and slight diuretic effect could be found without any changes in $Na^+$ and $K^+$ excretion.

Keywords