Environmental Analysis Health and Toxicology
- Volume 11 Issue 3_4
- /
- Pages.1-10
- /
- 1996
- /
- 2671-9525(eISSN)
Study on the Subacute Toxicity of Anticancer Platinum Complexese
개발한 제3세대 항암제의 아만성 독성연구
Abstract
The purpose of this study was to characterise the subacute toxic potency of i.v. administered KHPC-005 and 006. Few test compounds-related toxic effects were observed in body weight gain, clinical signs, urinalysis, hematological parameters and serum biochemical values. Gross necropsy and histopathology revealed no evidance specific toxicity. Our data indicated that no-observed effect level of KI-IPC-005 and 006 were estimated to be 10mg/kg and 4mg/kg in male rats, and 10mg/kg and 1.33mg/kg in female rats, respectively.
Keywords