Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

A Study on the development of high-fiber supplements for the diabetic patients (I) -Effect of Seaweed Supplementation on the Gastrointestinal Function and Diabetic Symptom Control in Streptozotocin-induced Diabetic Rats-

당뇨병 환자를 위한 고식이섬유 보충물의 개발을 위한 연구(I) -해조류 투여가 당뇨쥐의 장기능과 증세호전도에 미치는 영향-

  • 이혜성 (경북대학교 생활과학대학 식품영양학과)
  • Published : 1996.04.01
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Abstract

The present study was conducted to evaluate the usefulness of four kinds of seaweeds (mixture of purple laver & sea lettuce, sea tangle, sea mustard, agar agar) as a high- fiber supplment in the therapeutic deit for the diabetic patients. Seven groups of normal and streptozotocin-induced diabetic rats were fed dietary fiber-free control diet or one of experimental diets containing 7% of one of the four seaweeds for 6 weeks. The effect of seaweeds supplementation on the body weight change, gastrointestinal function, and the control of diabetic symptoms were examined and compared with the effect of fiber-free diet or pectin diet used as references. The body weight gains of all the diabetic groups were significantly suppressed compared to the normal group. Feed efficiency ratios and body weight gains of seaweed groups were relatively higher than those of the pectin group. Sea tangle appeared to have an effect of alleviating the typical diabetic symptoms such as polyphasia, polydipsia, polyuria, urinary glucose excretion and hyperglycemia indicating its beneficial acition of improving glucose metabolism even though the degree of effectiveness was less than that with pectin. All the supplemntations of seaweeds and pectin ressulted in the significant changes in gastronitestinal functins ; shortening of GI transit time, increase of fecal volume and the length of intestine. Based on their effects of the significant changes in GI function in may be suggested that seaweeds may influence the process of digestion and absorption of nutrients in diabetic animals.

Keywords

References

  1. J Am Diet Assoc v.88 Position of the American Diabetic Association : Health implications of dietary fiber American Diabetic Association
  2. Diabetes Care v.11 Dietary fiber in management of diabetes Viniik,A.T.I.;Jenkins,D.J.A.
  3. J Am Diet Assoc v.88 The effect of diet on plasma lipids, lipoproteins and coronary heart disease Kris Ethertan PM;Krumel,D.;Russell,M.E.(et al.)
  4. Physiological effects and health consequences of dietary fiber Federation of American Societies for Experimental Biology. Life Sciences Research Office
  5. Am J Gastroenterol v.81 Dietary fiber : Diabetes and obesity Anderson,J.W.;Bryant,C.A.
  6. Diabetes Care v.10 Nutritional recommendations and principles for individuals with diabetes mellitus American Diabetes Association
  7. 당뇨병의 식품교환 지침 대한당뇨병학회;대한영양사회;한국영양학회
  8. Am J Clin Nutr v.32 Dietary fiber and blood lipids : Reduction of serum cholesterol in typeⅡ hyperlipidemia by guar gum Jenkins,D.J.A.;Leeds,A.R.;Slavin,B.;Mann,J.;Jepson,E.M.
  9. Am J Clin Nutr v.58 Long term effects of guar gum in subjects with non-insulin-dependent diabetes mellitus Groop,P.H.;Aro,A.;Stenman,S.;Groop,L.
  10. Curr Therapeut Res v.30 Long-term dietary supplementation with a fiber product (guar gum) in elderly diabetics Kyllastinen,M.;Lahikainen,T.
  11. Lancet v.2 Effect of pectin, guar gum, and wheat fibre on serum-cholesterol Jenkins,D.J.A.;Leeds,A.R.;Newton,C.;Cummings,J.H.
  12. Am J Clin Nutr v.30 Effect of citrus pectin on blood lipids and fecal seroid excretion in man Kay,R.M.;Truswell,A.S.
  13. Am J Clin Nutr v.40 Hypocholesterolemic effects of oat-bran or bean intake for hypercholesterolemic men Anderson,J.W.;Story,L.;Sieling,B.;Chan W-JL;Petro,M.S.;Stroy,J.
  14. Diabetic Medicine v.2 Guar. Pharmacology fiber of food fiber? Peterson,D.B.;Mann,J.I.
  15. Br Med J v.2 Guar crispbread in the diabetic diet Jenkins,D.J.A.;Wolever,T.M.S.;Nineham,R.;Taylor,R.;Metz,G.L.;Bacon,S.;Hockaday,T.D.R.
  16. Ann Nutr Metab v.28 Effect of guar enriched pasta in the treatment of diabetes and hyperlipidemia Gatti,E.;Catenazzo,G.;Camisasca,E.;Torri,A.;Denegri,E.;Sirtori,C.R.
  17. Eur J Clin Nutr v.42 Evaluation of guar biscuits for use in the management of diabetes : Tests of physiological effects and palatability in non-diabetic volunteers Ellis,P.R.;Kanalanathan,T.;Dawoud,F.M.;Strange,R.N.;Coultate,T.P.
  18. 대한내과학회지잡지 v.26 Glucomannan이 성인형 당뇨병환자의 당질 및 지질대사에 미치는 영향 이태희;김양순
  19. 한국영양학회지 v.22 Guar gum이 type-Ⅱ 당뇨병 환자의 혈액성분에 미치는 영향 김은미;장유경
  20. 당뇨병 v.13 인슐린 비의존형 당뇨병에서 Guar gum의 당질 및 지질대사에 대한 영향 김성운;장영운;양인명;김진우;김영설;김광원;최영길
  21. 당뇨병 v.14 인슐린 비의존형 당뇨병의 치료에 있어서 식이섬유(Guar gum)의 효과 김유리;이현철;조병연;허갑범
  22. 당뇨병 v.18 인슐린 비의존성 당뇨병 환자의 식이섬유 섭취실태 이연경;이혜성;김보완
  23. J Sci Food Agric v.54 Marine algae as sources of fibres : Determination of soluble and insoluble dietary fibre contents in some 'sea vegetables' Lahaye,M.
  24. J Assoc Off Anal Chem v.71 Determination of insoluble, soluble and total dietary fiber in foods and food products : Interlaboratory study Prosky,L.;Asp,N.G.;Schweizer,T.F.;Devries,J.W.;Furda,I.
  25. Principles and procedures of statistics Steel,R.G.D.;Torrie,J.H.
  26. Lipids v.28 Diabetes increases excretion of urinary malonaldehyde conjugates in rats Daniel,D.G.;Saari,C.;Don,W.S.;Judith,M.O.
  27. Am J Clin Nutr v.38 Effect of brown rice and soybean dietary fiber on the control of glucose and liid metabolism in diabetic rats Zacharia,M.
  28. Lancet v.2 Food fiber as an obstacle to energy intake Heaton,K.W.
  29. Diabetes v.22 Increased kidney size and glomerular fitration rate in early juvenile diabetes Mogensen,C.E.;Anderson,M.J.F.
  30. Lipids v.28 Diabetes increases excretion of urinary malonaldehyde conjugates in rats Gallaher,D.D.;Csallany,A.S.;Shoeman,D.W.;Olson,J.M.
  31. Clin Sci Mol Med v.51 Renal hypertrophy in streptozotocin-diabetic rats Seyer-Hansen,K.
  32. Diabetologia v.13 Renal hypertrophy in experimental diabetes : Relation to severity of diabetes Seyer-Hansen,K.
  33. 糖尿病 v.25 糖尿病の診斷に關する委員會報告 小坂樹德他
  34. 한국영양학회지 v.27 식이섬유 첨가식이 streptozotocin-유도 당뇨쥐의 장기능과 지질 및 당질대사에 미치는 영향 박수현;이연경;이혜성
  35. New developments in dietary fiber Gastrointestinal responses to dietary fiber Schneeman,B.O.;Furda,I.(ed.);Brine,C.J.(ed.)
  36. Experientia v.47 The physiological and nutritional importance of dietary fiber Schweizer,T.H.;Wursch,P.
  37. J Jpn Soc Nutr Food Sci v.39 Effects of dietary fiber source on feces output and transit time in alimentary canal of mice Takehisa,F.
  38. 한양대학교 대학원 석사논문 식이섬유질의 종류와 함량이 장의 기능과 형태에 미치는 영향 박정난
  39. Human nutrition a comprehensive treatise, nutrition and the adult-macronutrients v.3a Nutrients with special functions-dietary fiber Story,J.A.;Kritchevsky,D.;Slater,R.B.A.(ed.);Kritchevsky,D.(ed.)
  40. Am J Clin Nutr v.32 Plant fiber carbohydrate and lipid metabolism Anderson,J.W.;Chen,W.J.L.
  41. Am J Clin Nutr v.40 Hypocholesterolemic effects of oat-bran or bean intakes for hypercholesterolemic men Anderson,J.W.;Story,L.;Sieling,B.;Chen,W.J.L.;Petro,M.S.;Story,H.
  42. Am J Clin Nutr v.31 A review of research on effects of fiber intakes on man Kelsay,J.L.
  43. Br J Nutr v.42 The effect of pectin on the structure and function of the rat small intestine Brown,R.C.;Kelleher,J.;Losowsky,M.S.
  44. J Nutr v.117 Intestinal structural changes in African green monkeys after long term psyllium or cellulose feeding Paulin,I.;Mehta,T.;Hargis,A.