Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Inhibition of Corticosterone-induced Muscle Protein Synthesis by the Anabolic Steroid Nandrolone Phenylpropionate in Female Rats

아나보릭스테로이드인 Nandrolone Phenylpropionate가 암컷 쥐에서 코티코스테론에 의해 야기된 근육단백질 쇠퇴와 근육단백질 합성율 감소에 미치는 영향

  • 주종재 (군산대학교 식품영양학과)
  • Published : 1996.10.01
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Abstract

This study was undertaken to determine whether the anabolic steroid nandrolone phenylpropionate(NPP) can inhibit the muscle atrophy and reduction in muscle protein synthesis caused by glucocorticoids in female rates. Daily injections of 50mg/kg of corticosterone for eight days induced significant reductions in body weight gain and protein without affecting food intake. The mass, protein and RNA content, ratio of RNA to protein, and fractional rate of protein synthesis, measured in vivo, of gastrocnemius muscle were all significantly reduced by corticosterone treatement. Simultaneous administration of NPP at a dose of 10mg/kg with corticosteorne (50mg/kg) fully inhibited the reductions in the mass, protein and RNA content of gastrocnemius muscle, and body weight gain and protein with no alteration in food intake but the reduction in fractional rate of muscle protein syntheis was only partially prevented. The results indicate that the anabolic steroid nandrolone phenylpropionate is capable of preventing muscle atrophy in female rats treated with excess corticosterion.

Keywords

References

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