Journal of Food Hygiene and Safety (한국식품위생안전성학회지)
- Volume 11 Issue 2
- /
- Pages.115-121
- /
- 1996
- /
- 1229-1153(pISSN)
- /
- 2465-9223(eISSN)
Antigenotoxicity of Quercetin and its Glycosides
Quercetin 및 Quercetin 배당체들의 유전독성억제효과
Abstract
In order to compare the suppressive effect of quercetin and several its glycosides, such as quercitrin (quercetin-3-rhamnoside), isoquercitrin (quercetin-3-glucoside), hyperin (quercetin-3-galactoside) and tutin (quercetin-3-rhamnosyl glucoside), on the genotoxicity by N-methyl-N-nitrosourea(MNU), in vitro sister chromatid exchange(SCE) test using mouse spleen lymphocytes and in vivo micronucleus test using mouse peripheral blood were performed. MNU-induced SCEs in vitro were not decreased by the simultaneous treatment of test compounds. Among them, quercetin and hyperin showed significant suppressive effects at high dose(10-5M). On the other hand, MNU-induced micronucleated reticulocytes(MNRETS) in vivo were significantly decreased with good dose-dependent manner in all compound tested. However, there were not significant differences between quercetin aglycone and its glycosides in the suppressive aglycone and its glycosides may act as an antigenotoxic agent in vivo and may be useful as a chemopreventive agent of alkylating agent.
Keywords
- Quercetin, Quercetin glycosides;
- Flavonoids;
- Antigenotoxicity;
- Sister chromatid exchange test;
- Micronucleus test;
- Cancer chemopreventive agent