생명과학회지 (Journal of Life Science)

  • 제6권3호
  • /
  • Pages.178-184
  • /
  • 1996
  • /
  • 1225-9918(pISSN)
  • /
  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지

기억. 학습장애 동물모델 SAMP8에 미치는 알로에(Aloe vera)의 영향 II. SAMP8의 지질대사에 미치는 알로에의 투여효과

Effect of Aloe on Learning and Memory Impairment Animal Model SAMP8 II. Feeding Effect of Aloe on Lipid Metabolism of SAMP8

  • 최진호 (부경대학교 식품생명과학과) ;
  • 김동우 (부경대학교 식품생명과학과) ;
  • 유제권 (한국화학연구소 안전성연구센터) ;
  • 한상섭 (한국화학연구소 안전성연구센터) ;
  • 심창섭 (김정문알로에 기술연구소)
  • 발행 : 1996.09.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Aloe(Aloe vera LINNE) has been used as a home medicine for the past several thousand in the world, and has been studied on various chronic degenerative diseases such as atherosclerosis, myocardiac infarction and hypertension. SMAP8, learning and memory impairment animal mode, were fed basic or experimental diets with 1.0% of freeze dried(FD)-Aloe powder for 8 months. This study was designed to investigate the effects of Aloe on body weight gain, grading score of senescence(GSS), triglyceride, total and LDL-cholesterol levels, and atherogenic index in serum of SAMP8, and also designed to investigate the effects of Aloe on cholesterol accumultions in mitochondria and microsome fractions of SAMP8 brain. Body weight gain was consistently lower in aloe group than in control group, but no significantly differences between them. Grading score of senescence resulted ina marked decreases pf 20% in 1.0% Aloe group compared with control group. Administrations of 1.0% aloe resulted ina marked decreases in 15% and 20% of triglyceride and cholesterol levels, respectively, and also significantly decreased in 15% of LDL-cholesterol levels and atherogenic index in serum of SAMP8 compared with control group. Cholesterol accumulations were significantly inhibited in 20% and 10% of mitochondria and microsome fractions of SAMP8 brain, respectively, by administration of 1.0% Aloe. These results suggest that administration of Aloe mau not only effectively inhibit chronic degenerative diseases in serum of SAMP8, but may also improve learning and memory impairments of SAMP8 brain.

키워드

참고문헌

  1. Annu Rev. Neurosci. v.9 New perspective on Alsheimer's disease Price, D. L.
  2. J. Neuropath Neurobiol. v.53 Alzheimer's disease; A central role for amyloid Selkoe, D. J.
  3. Senile Dementia;Outlook for the furture Transmission of unconventional slow virus disease and the relevance to SD/SDAT transmission studies, Alan R. Liss Carp, R. I.;Merz, G. S.;Wisniewski, H. M.;J. Wertheimer(ed.);M. Marais(ed.)
  4. Acta. Neurologica Acandinavia, Supplementum v.99 Senile dementia of the Alzhiemer's type: Possibility of and infectious etiology in genetically susceptible individuals Wisniewski, H. M.;Merz, G. S.;Garp, R. I.
  5. Acta. Neuropathologica v.75 Ultrastructural studies of glycoconjugated in brain micro-blood vessels and amyloid plaques of scapie-infected mice Vorbrodt, A. W.;Dobrogowska, D. H.;Kim, Y. S.;Lossinsky, A. S.;Wisniewski, H. M.
  6. Acta. Neuropathol. v.80 Incubation periods and histophological changes in mice injected sterotoxically in different brain areas with the 87V scrapie strain Kim, Y. S.;Carp, R. I.;Callahan, S. M.;Wisniewski, H. M.
  7. Arch Intern Pharmacodya. v.120 no.2 The mechanism of the hypotensive effect of lignum aloes Benbassat, J.;Sulman, F. G.;Zaitschek, D. V.
  8. Klin Khir v.11 Results of conservstive treatment of patients with endarteriosis and atherosclerosis of vessels of the extremities in out and in patients conditions Zaitsev, G. P.;Poriadin, V. T.;Rozenfel'd, E. S.
  9. Japan Kodai JP 53059019 v.6 Anti-inf-lammatory compositions containing aloe extracts and steroids Shinpo, M.;Kameyama, S.;Tokita, F.
  10. Oftalmol. Zh. v.6 Moderate local hypothermia and its use in certain eye diseases Chanchikiv, G. F.;Miminoshvili Sla
  11. Arch. Inst. Pasteur Madagascar v.47 no.1 Immunostimulant properties of an extract isolatied and partially purified from aloe vahombe Solar, S.;Zeller, H.;Rasolofonirina, N.;Coulanges, P.(et al.)
  12. Belg. BE 892207 A2 Weight control composition De Valck, W.
  13. U.S. Pharmacist Medical use of aloe products Fischer, J. M.
  14. Fureguransu Janaru v.11 no.3 Pharmaceutical effect and application of aloe to medicine Suzuki, Y.
  15. Acta Dermatol Venereol v.62 no.1 Inhibition of arachidonic acid oxidation in vitro by vehicle components Penneys, N. S.
  16. The SAM Model of Senescence Senes-cence-accelerated mouse(SAM). A novel murine model of aging Takeda, T.;Hosokawa, M.;Higuchi, K.;To-shio Takeda(ed.)
  17. J. Biol. Chem. v.193 Protein measurement with the Folin-Phenol reagent Lowry, O. H.;Roseborough, N. J.;Farr, L. A.;Randall, R. J.
  18. J. Lipid Res. v.14 Determination of cholesterol using o-phthalaldehyde Rudel, L. L.;Morris, M. D.
  19. Clin. Chem. v.24 Simulataneous determination of serum cholesterol in high and low density lipoprotein with use of heparin, Ca^{2+}, and an anion exchnge resin Noma, A.;Nakayama, K. N.;Kita, M.;Okabe, H.
  20. Kor. J. Gerontol. v.3 no.2 Effect of wild dropwort extract on physiological activity of rats Choi, J. H.;Kim, J. I.;Kim, D. W.;Moon, Y. S.;Yoon, T. H.
  21. E. J. Nutr. v.121 The effects of fish oil on triglycerides, cholesterol, fibrinogen and malondialdehyde in humans supplemented with vitamin Haglund, O.;Luostarinen, R.;Wallin, R.;Wibell, L.;Saldeen, T.
  22. Principles and procedures of statistics Steel, R. G. D.;Torrie, J. H.
  23. Korean J. Life Science v.6 no.2 Effect of Aloe on learning and memory impairments in dementia animal model SAMP8 st-rain Ⅲ. Feeding dffect of Aloe om neurotransmitters and their metabolites in SAMP8 Choi, J. H.;Kim, D. W.;Kim, J. I.;Han, S. S.;Shim, C. S.
  24. AGE v.19 Analysis of lipid composition and hydroxyl radicals in brain membranes of senescence-accelerated mice Choi, J. H.;Kim, J. I.;Kim, D. W.;Moon, Y. S.;Chung, H. Y.;Yu, BP.