Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effect of Aloe on Learning and Memory Impairment Animal Model SAMP8 II. Feeding Effect of Aloe on Lipid Metabolism of SAMP8

기억. 학습장애 동물모델 SAMP8에 미치는 알로에(Aloe vera)의 영향 II. SAMP8의 지질대사에 미치는 알로에의 투여효과

  • 최진호 (부경대학교 식품생명과학과) ;
  • 김동우 (부경대학교 식품생명과학과) ;
  • 유제권 (한국화학연구소 안전성연구센터) ;
  • 한상섭 (한국화학연구소 안전성연구센터) ;
  • 심창섭 (김정문알로에 기술연구소)
  • Published : 1996.09.01
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Abstract

Aloe(Aloe vera LINNE) has been used as a home medicine for the past several thousand in the world, and has been studied on various chronic degenerative diseases such as atherosclerosis, myocardiac infarction and hypertension. SMAP8, learning and memory impairment animal mode, were fed basic or experimental diets with 1.0% of freeze dried(FD)-Aloe powder for 8 months. This study was designed to investigate the effects of Aloe on body weight gain, grading score of senescence(GSS), triglyceride, total and LDL-cholesterol levels, and atherogenic index in serum of SAMP8, and also designed to investigate the effects of Aloe on cholesterol accumultions in mitochondria and microsome fractions of SAMP8 brain. Body weight gain was consistently lower in aloe group than in control group, but no significantly differences between them. Grading score of senescence resulted ina marked decreases pf 20% in 1.0% Aloe group compared with control group. Administrations of 1.0% aloe resulted ina marked decreases in 15% and 20% of triglyceride and cholesterol levels, respectively, and also significantly decreased in 15% of LDL-cholesterol levels and atherogenic index in serum of SAMP8 compared with control group. Cholesterol accumulations were significantly inhibited in 20% and 10% of mitochondria and microsome fractions of SAMP8 brain, respectively, by administration of 1.0% Aloe. These results suggest that administration of Aloe mau not only effectively inhibit chronic degenerative diseases in serum of SAMP8, but may also improve learning and memory impairments of SAMP8 brain.

Keywords

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