생명과학회지 (Journal of Life Science)

  • 제6권3호
  • /
  • Pages.159-164
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  • 1996
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  • 1225-9918(pISSN)
  • /
  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지

Orotic acid 유발 지방간 rat 와 mouse의 중성지질 대사

Effect of Dietary Orotic Acid on Triglyceride Metabolism in Rats and Mice

  • 조영수 (동아대학교 생명자원과학대학 농화학과) ;
  • 차재영 (일본좌가대학응용생물과학과)
  • 발행 : 1996.09.01
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초록

Effects of 1% dietary orotic acid on triglyceride metabolism were examined in SD-rats and Kud: ddY mice. When rats were fed semisynthetic diet containing 1% orotic acid and n-6 polyunsaturated fatty acid (linoleic acid), the hepared diet. In contrast to rats which respond to orotic acid consumption with increases in hepatic triglyceride content, mice did not so respond. The rats-limiting step in triglyceride synthesis is catalyzed by the enzyme phosphatic acid phosphohydrolase (EC3.1.3.4) which is present in the liver cytosol and microsomes of rats fed oroic acid diet. This finding suggests that the activity of this enzyme may play a tole in the fatty liver formation in rats.

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참고문헌

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