Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Acute Toxicity of Recombinant Human Erythropoietin (rHu-EPO) in Beagle Dogs

비글개에서 인체 재조합 적혈구 조혈인자, rHu-EPO의 급성독성에 관한 연구

  • Cho, Myung-Hang (College of Veterinary Medicine, Seoul National University) ;
  • Seong, Ha-Jung (College of Veterinary Medicine, Seoul National University) ;
  • Kim, Hyung-Sik (Division of Toxicology, Scool of Pharmacy, Sung Kyun Kwan University) ;
  • Kwack, Seung-Jun (Division of Toxicology, Scool of Pharmacy, Sung Kyun Kwan University) ;
  • Chun, Sun-Ah (Division of Toxicology, Scool of Pharmacy, Sung Kyun Kwan University) ;
  • Lim, So-Young (Division of Toxicology, Scool of Pharmacy, Sung Kyun Kwan University) ;
  • Kim, Won-Bae (Dong-A Pharm. Co., LTD.) ;
  • Kim, Byoung-Moon (Dong-A Pharm. Co., LTD.) ;
  • Ahn, Byoung-Ok (Dong-A Pharm. Co., LTD.) ;
  • Lee, Byung-Mu (Division of Toxicology, Scool of Pharmacy, Sung Kyun Kwan University)
  • Published : 1996.12.01
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Abstract

The acute toxicity of rHu-EPO, newly developed recombinant erythropoietin, was tested in beagle dogs. rHu-EPO, when administered intravenously at 25, 000 IU/kg, did not cause any death. Also, rHu-EPO did not induce any change of body weight, food intake and clinical signs compared to controls. There were no significant changes in hematological, urine analysis and pathological examination. These results showed that rHu-EPO did not induce any remarkable toxic response and the $LD_50$ was greater than 25, 000 IU/kg in beagle dogs.

Keywords

References

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