Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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A Study on the Preventive Effect of Chitosan on the Lead Toxicity in Rats

흰쥐의 납독에 대한 키토산의 효과에 관한 연구

  • 김일두 (조선대학교 화학과) ;
  • 유문희 (이리 농공전문대학 식품공업과)
  • Published : 1996.12.01
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Abstract

This study was performed to investigate the effects of chitosan on the lead poisoning in rats. For this experiment, 15 male Sprague-Dawley rats were used. The experimental groups were divided into five: Control (250 mg/kg lead), Group I (250 mg/kg lead+1% chitosan), Group II (250 mg/kg lead+2% chitosan), Group III(250 mg/kg lead+4% chitosan), Group IV (250 mg/kg lead+8% chitosan). The results were as follows; 1. The lead concentration in the liver showed 3.924~10.217 mg/kg in control group, but treated group was inclined to decrease during the experiment period (P<0.05). 2. The lead concentration in the kidney showed 23.268~31.315 mg/kg in control group, but Experimental group showed 3.765~9.725 mg/kg (Group I), 34.60~9.115 mg/kg (Group II), 3.549~8.816 mg /kg (Group III), 3.502~8.532 mg/kg (Group IV) resectively, also, Experimental group was inclined to decrease compared to control group (P

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References

  1. 한국영양학회지 v.19 no.4 단백질 급원과 수준을 달리한 식이가 흰쥐 납축적에 미치는 영향 김옥경;서정숙;이명환
  2. 전북대학교 박사학위논문 대기 및 수질오염 지역에 토양 및 수도체중의 중금속 함량 김성조
  3. 한국산업의학 v.24 no.1 연제련 근로자들의 만성적 연폭로에 관한 연구 김정만;이세훈;이은영;조영선
  4. 대한 산업의학회지 v.3 no.2 연 취급 근로자들의 면역능에 관한 조사 류철인;조병만;이지호;황인경;이수일;김돈균
  5. 대한산업의학회지 v.2 no.2 고속도로 톨게이트 근로자들의 연 폭로 및 자각증상에 관한 연구 박정임;구정완;노영만;이승한
  6. 국립환경연구소보 v.4 하천부지 토양중의 중금속 함량 조사와 동광산지역 농경지의 중금속 실태조사 서봉수;문화회;김인기;김학엽;전성환
  7. 생태내에 있어서 오염물질의 이동체계에 관한 연구 이광우;이수형;양승범;오재룡;김은주
  8. 연세의대 학위논문집 희쥐에서 만성 납중독이 뇌의 Biogemic Amine 함량에 미치는 영향 이병철
  9. 한수지 v.6 no.1 한국산 어패류 중의 수은, 카드뮴, 납, 구리의 함량 원종훈
  10. 고분자학회지 v.14 no.4 활성화된 chitosan계 분리용 소재의 제조와 금속이온 분리능에 관한 연구 최규석;류영완
  11. Toxicology v.25 Celluar adaptation in metal toxicolgy and metallothionein Cherian,M.G.;Nordberg,M.
  12. Bull. Environ. Contam. Toxicol. v.15 Effects of chitosan acoggulating agent for food processing wastes in the diet of rats on growth and liver and blood consumption D.R.Landes;W.A.Bough
  13. Toxicol Appl Pharmacol. v.66 Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionelin in biological tissues Eaton,D.L.;Toal,B.F.
  14. Toxicology and Applied Pharmacology v.99 Mechanism by which Lead Depresses Linear and Ponderal Growth in Weanling Rats Hammound,P.B.;Chernausek,S.D.;Succop,P.A.;Shukla,R.;Bornschein,R.L.
  15. Biotechnol. Bioeng v.21 Alkaline Phosphatase and Pepsin immobilized in gels Hirano,S.;Miura,O.
  16. J. Biol. Chem. v.236 Metallothionein;A cadmium and zinc-containing protein from equine renal cortex Kage,J.H.R.;Vallee,B.L.
  17. Toxicol Appl Pharmacol. v.41 Toxicity and distribution of cadmium administered to rats at sublethal doses Kostonis,F.N.;Klaassen,C.D.
  18. Geneva v.12 Encyclopaedia of Occupational Health and Safety(Third Edition) Luigi,P.
  19. J. Appl. Biochem. v.3 The production of chitosans of superiou quality Muzzarelli,R.A.A.;Tanfani,F.
  20. Eisei Kagaku v.24 A simplified procedure for determination of metallothionein in animal tissues Onosaka,S.;Tanak,K.;Doi,M.;Okahara,K.
  21. Biochemistry v.5 Isolation and some properties of human metallothionein Pulido,P.Kage;Vallee,B.L.
  22. Nutrition Reprots Int. v.27 Invivo dye-binding of chitin and its effect on gerbil growth and gut function T.R.Watkins;D.Knorr
  23. Toxicology and Applied Pharmacology v.76 The Influence of Milk Kiet, Grain Diet, and Method of Dosing on Lead Toicity in Young Calves Zmudzki,J.;Bratton,G.R.;Womac,C.;Rowe,L.D.