Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Effect of Dietary Protein Content on the Toluene Metabolism in Rats

식이성 단백질 함량이 Toluene 대사에 미치는 영향

  • 윤종국 (계명대학교 자연과학대학 공중보건학과) ;
  • 김경순 (계명대학교 자연과학대학 공중보건학과) ;
  • 전태원 (계명대학교 자연과학대학 공중보건학과)
  • Published : 1996.12.01
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Abstract

To study an effect of toluene administration on the toluene metabolism in rats liver previously fed a low (casein 7%, LP) or standard (casein 20%, SP) protein diet, toluene (50% in olive oil) was given at 0.2 ml per 100 g body weights once daily during 4 days to the male rats. The content of hepatic cytochrome P-450 was higher in rats fed SP than those fed LP. The hepatic benzylalcohol dehydrogenase activity was higher both in toluene-treated rats and its control group fed SP than those fed LP. The hepatic benzaldehyde dehydrogenase activity was somewhat higher in rats fed SP than those fed LP. In the case of toluene treatment, the increasing rate of hippuric acid contents to the control group were higher in rats SP than those fed LP. In conclusion, it is likely that the metabolic rate of toluene would be higher in rats fed SP than those fed LP.

Keywords

References

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