Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Teratological Studies of Ginkgo biloba Extract(EGb 761) in Rabbits

  • Lee, Yong-Soon (Laboratory of Public Health) ;
  • Nam, Jeong-Seok (Laboratory of Public Health) ;
  • Che, Jeong-Hwan (Laboratory of Public Health) ;
  • Lee, Suk-Man (Laboratory of Public Health) ;
  • Yang, Jae-Man (Laboratory of Public Health) ;
  • Kang, Byeong-Cheol (Laboratory of Public Health) ;
  • Lee, Hak-Mo (Laboratory of Public Health) ;
  • Park, Jae-Hak (Laboratory Animal Medicine) ;
  • Kim, Dai-Yong (Laboratory of Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Kang, Sung-An (YuYu Industrial Co., LTD Research Center)
  • Published : 1996.06.01
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Abstract

A teratological study was performed using New Zealand White rabbits to examine the teratological potential of Ginkgo biloba extract(EGb 761), which is a known strong platelet activating factor antagonist. Ginkgo biloba extract(EGb 761) was administered per intravenously during the organogenesis period (day 6th to 18th of gestation) of rabbits at dose levels of 7.5, 15, and 30 mg/kg/day. All pregnant females were sacrificed on day 29 of gestation and teratological abnormalities of their fetuses was examined. No statistically significant difference of body weight change between control and treated groups during experimental periods was noted. There was no statistically signifiant difference of numbers of corpus lutes and implantations, fetal death ratio, fetal sex ratio, and placental weight between control and rabbits exposed to three different concentration ranges of Ginkgo biloba extract (EGb 761). No marked external, visceral and skeletal abnormalities related to Ginkgo biloba extract(EGb 761) were observed in the fetuses. In conclusion Ginkgo biloba extract(EGb 761) does not show any effect on implantation or embryonic development.

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References

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