Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Three Month Subacute Toxicity Study of Ginkgo Biloba Extract(EGb 761) in Rats

  • Lee, Yong-Soon (Laboratory of Public Health) ;
  • Nam, Jeong-Seok (Laboratory of Public Health) ;
  • Che, Jeong-Hwan (Laboratory of Public Health) ;
  • Lee, Suk-Man (Laboratory of Public Health) ;
  • Yang, Jae-Man (Laboratory of Public Health) ;
  • Kang, Byeong-Cheol (Laboratory of Public Health) ;
  • Lee, Hak-Mo (Laboratory of Public Health) ;
  • Park, Jae-Hak (Laboratory of Public Health) ;
  • Chai, Chan-Hee (Laboratory of Public Health) ;
  • Kang, Sung-An (Laboratory of Public Health)
  • Published : 1996.06.01
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Abstract

Group of 40 male and 40 female Sprague-Dawley rats was given daily intravenous injections of different dosage of Ginkgo biloba extract(EGb 761), 7.5 mg/kg/day (low dosage group), 15 mg/kg/day (middle dosage group), or 30 mg/kg/day (high dosage group)for 3 month by tail vein according to Established Regulation of Korean National Institute of Safety Research (1994. 4. 14). Appearance, behavior, mortality, and food consumption of rats of treated groups were not affected during the experimental periods. No significant Ginkgo biloba extract(EGb 761)-related changes were found in urinalysis, hematology, serum chemistry, and organ weight. No histopathological lesions were seen in both control and treatment groups. Our results strongly suggest that no toxic changes were found in rat treated intravenously with Ginkgo biloba extract(EGb 761)for 3 month.

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References

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