The Korean Journal of Zoology (한국동물학회지)
- Volume 39 Issue 3
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- Pages.299-306
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- 1996
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- 0440-2510(pISSN)
Effects of Antimetabolite 6-Aminonicotinamide on Levels of Free Amino Acids in Various Tissues of Quail
항 대사물질 6-Aminonicotinamide가 메추리 조직 내 유리 아미노산에 미치는 영향
- Mok, Chang-Soo (Department of Applied Biology, Dongguk University) ;
- Kim, Jae-Young (Department of Applied Biology, Dongguk University) ;
-
Shin, Sook
(Department of Biology, Korean Sahmyook University)
;
- Park, In-Kook (Department of Applied Biology, Dongguk University)
- Published : 1996.07.01
Abstract
The effects of antimetabolite 6-aminonicotinamide on levels of soluble proteins, free amino acids and protease activity in various tissues of quail have been in vestigated. The levels of soluble proteins m liver, heart and pectoral muscle were markedly lowered and the specific activity of protease in kidney and pectoral muscle was markedly increased. The concentrations of aspartic acid / asparagine, alanine, valine, methionine, isoleucine, leucine and lysine in the liver were markedly increased. En the kidney the concentrations of aspartic acid I asparagine, arginine, threonine, alanine, proline and lysine were markedly increased but those of glutamic acid I glutamine were decreased. The concentrations of glutamic acid / glutamine and serine in the heart were reduced but those in glycine and methionine were increased. In the pectoral muscle the concentration of arginine was decreased but the concentration of alanine and threonine was increased. The overall results suggest that antimetabolite 6-aminonicotinamide may act to enhance concentrations of amino acids related to the generation of energy and to depress the biosynthesis of some specific amino acids.
항 대사물질 6-aminonicotinamide가 메추리 조직의 수용성 단백질, 유리 아미노산 및 단백질 가수분해효소에 미치는 영향을 조사하였다. 간(P<0.05), 심장(P<0.01), 흉부근육 조직(P<0.05)의 수용성 단백질의 함량은 대조군에 비해 현저히 감소하였다. 신장과 흉부근육 조직의 단백질 가수분해효소의 비활성도는 대조군에 비하여 현저히 감소하였다. 신장과 흉부근육 조직의 단백질 가수분해효소의 비활성도는 대조군에 비해 현저히 증가하였다. (P<0.05). 간(P<0.05)의 aspartic acid / asparagine, alanine, valine, methionine, isoleucine, leucine, lysine의 농도는 대조군에 비해 증가하였다. 신장(P<0.05)의 acid / asparagine, alanine, threonine, alanine, proline과 lysine은 증가하였으나 glutamic acid / glutamine의 농도는 감소하였다. 심장에서는 glycine과 methionine 농도는 증가하였으나 glutamic acid / glutamine의 농도는 감소하였다. 흉부근육 조직에서는 arginine의 농도는 감소하였으나 (P<0.05) alanine과 threonine의 농도는 증가하였다 (P<0.05). 본 연구 결과는 항 대사물질인6-aminonicotinamide가 유리 아미노산의 농도를 증가시키므로써 기포 물질 대사에 필요한 에너지를 유지하는 것으로 사료된다.