한국대기환경학회지 (Journal of Korean Society for Atmospheric Environment)

  • 제12권3호
  • /
  • Pages.269-278
  • /
  • 1996
  • /
  • 1598-7132(pISSN)
  • /
  • 2383-5346(eISSN)
한국대기환경학회 (Korean Society for Atmospheric Environment)
권호 표지

대기중 복합물질의 돌연변이원성과 인체 위해도

Health Risk of Airborne Complex Mixtures Based on their Mutagenicity

  • 박성은 (연세대학교 환경공해연구소) ;
  • 정용 (연세대학교 환경공해연구소)
  • Park, Seong-Eun (The Institute for Environmental Research, Yonsei University) ;
  • Chung, Yong (The Institute for Environmental Research, Yonsei University)
  • 발행 : 1996.11.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Airborne suspended particulates were collected by an Andersen high volume air sampler in a traffic area of Seoul from September 1990 to August 1991. Origanic matter extracted from particulates, their fractions, namely acidic, basic, neutral and carcinogenic subfractions (PAHs, nitroarenes) in neutral fractions were assayed for mutagenicity on TA98, TA100 and TA98NR deficient Salmonella strains, use of the pre-incubation method. The relative contribution to total mutanenicity of organic matters was highest in neutral fraction and was lowest in basic fraction. Among subfractions, that of neutral fraction was higher nitroarenes subfraction compared to PAHs subfraction. While the carcinogenic effect of benzo[a]pyrene was calculated as 0.96 persons/million persons based on unit risk estimates by extrapolation method, life time excess cancer risk estimate of EOM, neutral, PAH fraction based on their mutagenicity was calculated as 52, 42, 3.8 persons/million persons, respectively. These findings indicate that the mutagenic hazard of the partciculate, air organic complex mixture, may be dependent upon the mutagen composition in the particulate and interactions each of them. Therfore, health risk from air organic complex mixtures based on mutagenicity might be useful indicator for evaluation of actual risk.

키워드

참고문헌

  1. 한국대기보전학회지 v.18 no.1 대기 중 Benzo(a)pyrene의 외삽 방법에 따른 위해도 추계치의 비교연구 김종만;정용
  2. 한국대기보전학회지 v.8 no.4 서울시 대기부유분진의 농도와 다환방향족 유기오염물에 의한 발암 위해성 박성은;정용
  3. 예방의학회지 v.23 no.1 도시 대기 중 유기오염물질의 농도와 돌연변이원성에 대한 연구 신동천;정용;문영한;노재훈
  4. 예방의학회지 v.27 no.2 서울시 일부 교통지역의 대기부유분 중 유기오염물질에 대한 발암위해성 평가 신동천;정용;김종만;박성은;임영욱
  5. 약학회지 v.32 no.5 서울시 대기 중 부유분진의 입도별 돌연변이원성의 월변화 장재연;김박광;조성준;정용
  6. 약학회지 v.33 no.1 대기 중 부유분진에 함유된 유기물의 분획별 돌연변이원성 장재연;김박광;정용
  7. 환경보전협회지 v.4 서울시 대기오염물질의 돌연변이원성에 관한 연구 차철환;김영환;김재성
  8. Mut. Res. v.75 no.31 Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test Ames,B.N.;J.McCann;E.Yamasaki
  9. Yonsei Medical J. v.28 no.1 Physico-chemical nature and mutagenic activity of ambient dust in Seoul Chung,Y.
  10. Regula. Toxicol. and Pharma v.13 Risk assessment for benzo(a)pyrene Collins,J.F.;J.P.Brown;S.V.Dawson;M.A.Marty
  11. Cancer Lett. v.4 The mutagenicity of airborne particulate pollutants Dehnen,W.;N,Pitzs;R.Romingers
  12. Mut. Res. v.116 Genotoxicity of aerosol extracts: some methodological aspects and the contribution of urban and industrial locations De Raat,W.K.
  13. Environ. Int. v.9 Detection and average content levels of carcinogenic and mutagenic compounds from the particulates on diesel and gasoline engine mufflers Handa,T.;T.Yamauchi;M.Ohnishi;Y.Hisematsu;T.lshii
  14. Chromatographia v.19 The identification of nitrated polycyclic aromatic hydrocarbons in diesel particulate extracts and their potential formation as artifacts during particulate collection Hartlong,A.;J.Kraft;J.Schuzle;H.Kiess;K.H.Lies
  15. IARC monogr. Eval. Carcinog. Risk. Chem. Hum. v.32 International Agency for research on cancer benzo[a]pyrene International Agency for Research on Cancer
  16. Complex mixtures and cancer risk v.104 International Agency for Research on Cancer
  17. E.S.T. v.22 no.10 Polynuclear Aromation compounds and genotoxicity in particulate and vapor phases of ambient air: effect of traffic, season, and meteorological conditions Jari,T.
  18. Risk Analysis v.12 no.1 Carcinogenic mixtures Krewski,D.;R.D.Thomas
  19. Toxicology and Industrial Health v.5 Emerging methodogies for assessment of complex mixtures: application of bioassays in the integrated air cancer project Letwas,J.
  20. Environ. Health Perpect. v.100 Complex mixtures of air pollutants: charcterizing the cancer risk of polycyclic organic matter Letwas,J.
  21. Mut. Res. v.113 Revised methods for the Salmonella mutagenicity test Maron,D.M.;B.N.Ames
  22. Chemosphere v.17 no.6 Polar organic components in emission and immission samples from urban suspended particulates and then mutagenicity in the Ames-bioassay Moriske,H.J.;H.Ruden
  23. Toxicol. Lett. v.1 Mutagenic activity of airborne particulate organic pollutants Pitts,J.N.;Jr.D.Grosjean;T.M.Mischke;F.F.Simmon;D.Pook
  24. J. of Air Pollu. Cont. Associ. v.35 Diurnal mutagenicity of airborne particulate organic matter adjacent to a heavily traveled West Los Angeles freeway Pitts,J.N.;J.A.Sweetman;W.Harger;D.R.Fitz;R.Pour
  25. Mut. Res. v.101 Direct-acting mutagens in diesel exhaust; magnetude of the problem Rosenkranz,H.S.
  26. Arch. of Environ. Health v.42 no.1 Carcinogenicity of extract of airborne particles using new-born mice and comparative study of carcinogenic and mutagenic effect of the extract Sasaki,Y.;T.Kawai;K.I.Ohyama;A.Nakama;R.Endo
  27. Atmos. Environ. v.19 Contribution of bacterial mutagenicity from nitro-PAH compounds in ambient aerosols Siak,J.;T.L.Chan;T.L.Gibson;G.T.Wolff
  28. Mut. Res. v.56 Mutagenicity in Salmonella typhimurium mutants of benzen soluble organic matter derived from airborne particulates matter and its five fraction Teranishi,K.;K.Hamada;H.Watanabe
  29. Mut. Res. v.48 Detection of mutagenic activity in particulate air pollutants Tokiwa,H.;K.Morita;A.Takeyoshi;K.Takakashi;Y.Ohnishi
  30. Mut. Res. v.77 Mutagenic and chemical assay of extracts of airborne particulates Tokiwa,H.;S.Kitamori;K.Takahashi;Y.Ohnishi
  31. Mut. Res. v.48 Mutagenicities of N-nitrosamines of salmonella Yahagi,T.;M.Nagao;Y.Seino;T.Matsushima;T.Sugumura;M.Okada
  32. J. of Korea Air Pollution Research Association v.10 no.E Mutagenicity of diesel-exhaust particulates Yoo,Y.S.
  33. WHO Regional Publications, Europe series No. 23. Air quality guidence for Europe WHO