Journal of Chest Surgery

The Korean Society for Thoracic and Cardiovascular Surgery (대한심장혈관흉부외과학회)
권호 표지

Normal and Abnormal Development of the Heart

심장의 정상 및 이상발생

  • Seo, Jeong-Uk (Department of Pathology and Heart Research Intitute, Seoul National University College of Medicine) ;
  • Choe, Jeong-Yeon (Department of Pediatrics and Heart Research Intitute, Seoul National University College of Medicine) ;
  • Seo, Gyeong-Pil (Department of Thoracic and Cardiovascular Surgery, and Heart Research Intitute, Seoul National University College of Medicine) ;
  • Ji, Je-Geun (Department of Pathology, Seoul National University College of Medicine)
  • 서정욱 (서울대학교 의과대학 병리학교실 및 심장연구소) ;
  • 최정연 (서울대학교 의과대학 소아과교실 및 심장연구소) ;
  • 서경필 (서울대학교 의과대학 흉부외과학교실 및 심장연구소) ;
  • 지제근 (서울대학교 의과대학 병리학교실)
  • Published : 1996.02.01
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Abstract

Studies on normal human embryos and on malformed human hearts have been two main sources of the information on the developmental cardiology, Recent advances in the biological technology has opened a new era and descriptive embryology is being shifted into dynamic developmental biology. In this review, we discuss the current understanding on the cardiac embryology relevant to clinical practices of pediatric cardiology. Classical cardiac embryology starts with understanding on five segments of a straight heart tube : the sinus venosus, the primitive atria, the embryonic left ventricle, the embryonic right ventricle and the truncus arteriosus. Key steps in the normal morphogenetic process are the complex spiral septation of ventriculoarterial junction and two jumping connections : between the embryonic right atrium and embryonic right ventricle, and between the embryonic left ventricle and the aorta. Only after these two steps are successfully completed, the third fetal stage tak s place, when myocardial growth and remodeling take place There are two outstanding progresses on the cardiac embryology during recent five-year period. One is immunohistochemical mapping of the conduction system in the developing heart and the other is the understanding on the neural crest cell migration followed by molecular detection of the microdeletion of chromosome 22. A balanced progress of classical morphological studies, modern biological technics and advanced clinical medicine is an urgent task for doctors and scientists dealing with children with sick hearts.

Keywords

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