Archives of Pharmacal Research
- Volume 19 Issue 1
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- Pages.36-40
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- 1996
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Effect of Glycyrrhetinic acid on Histamine Synthesis and Release
-
Lee, Young-Mi
(Wonkwang University, School of Medicine)
;
-
Kim, Youn-Chul
(College of Pharmacy, wonkwang University)
;
- Kim, Hyung-Min (Wonkwang University, School of Medicine)
- Published : 1996.02.01
Abstract
The effect of glycyrrhetinic acid(18.betha.-glycyrrhetinic acid, GA) on histamine synthesis and release was investigated in cocultured mast cells with Swiss 3T3 fibroblasts. GA has strong dose dependent inhibitory activity for histamine synthesis and release in cocultured mast cells. GA(50 .mu.M) inhibited about 85% of histidine decarboxylase (HDC) activity. The appearance of cells staining positively with berberine sulface was also decreased in the presence of GA. It indicates that transdifferentiation of cultured mas cells (CMCs) was also inhibited.