Archives of Pharmacal Research
- 제19권5호
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- Pages.400-405
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- 1996
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Bacterial Resistance to LB20304, a New Fluoroquinolone Antibiotic
- Kim, Mu-Yong (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd.) ;
- Paek, Kyoung-Sook (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd.) ;
- Kim, In-Chull (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd.) ;
- Kwak, Jin-Hwan (School of Bioscience and Food Technology, Handong University)
- 발행 : 1996.10.01
초록
In vitro studies were conducted to dertermine the frequency rate of spontaneous resistance to LB20304 and to dertermine whether cross-resistance to other antimicrobial agents develops. In eight strains of bacteria, the frequency of mutation to LB20304 at the concentrations of four and eight times the minimal inhibitory concentration(MIC) ranaged from less than 4.0