Radiation Oncology Journal
- Volume 14 Issue 1
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- Pages.53-59
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- 1996
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- 2234-1900(pISSN)
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- 2234-3156(eISSN)
Postirradiation Changes of White Blood Cells and Lymphocyte Subpopulations in Cancer Patients
암환자의 방사선치료에서 흉부 및 전골반강 조사직후 백혈구 및 림프구아헝 변화에 대한 연구
- Ahn, Sung-Ja (Department of Therapeutic radiology, Chonnam University Medical School) ;
- Chung, Woong-Ki (Department of Therapeutic radiology, Chonnam University Medical School) ;
- Nam, Taek-Keun (Department of Therapeutic radiology, Chonnam University Medical School) ;
- Nah, Byung-Sik (Department of Therapeutic radiology, Chonnam University Medical School) ;
- Noh, Young-Hee (Department of Therapeutic radiology, Chonnam University Medical School)
- 안성자 (전남대학교 의과대학 치료방사선과학교실) ;
- 정웅기 (전남대학교 의과대학 치료방사선과학교실) ;
- 남택근 (전남대학교 의과대학 치료방사선과학교실) ;
- 나병식 (전남대학교 의과대학 치료방사선과학교실) ;
- 노영희 (전남대학교 의과대학 치료방사선과학교실)
- Published : 1996.03.01
Abstract
Purpose : Radiation-induced alteration in the immune function is well known phenomenon in cancer patients. Our purpose is to evaluate the extent of immune suppression immediately after mediastinal or pelvic irradiation, which include significant volume of active bone marrow in adults. Materials and Methods'48 cancer patients with mediastinal(N=29) and pelvic irradiation(N=19) were the basis of this analysis. Age ranged from 36 to 76 and mean and median value was 57 years, respectively Sex ratio was 1.3(M: F=27/21). The immunological parameters were the complete blood cell(CBC) with differential cell(D/C) count, T cell subset(CD3, CD4, CD8 CDl9), NK cell test(CDl6, CD56), and serum immunoglobulin(IgG, IgA, IgM) level. Results : The mean value of white blood cell(WBC) was reduced from 7017 to 4470 after irradiation(p=0.0000). In the differential count, the number of lymphocyte, neutrophil, and basophil was markedly reduced with statistical significance(p<0.01) and the number of monocyte was not changed and, on the contrary, that of eosinophil was increased by irradiation. In the lymphocyte subpopulation analysis, the number of all subpopulations, CD3(T cell), CD4(helper T cell), CD8(suppressor T cell), CDl6(NK cell), CDl9(B, cell) was reduced with statistical significance. The mean ratio of CD4 to CD8 in all patients was 1.09 initially and reduced to 0.99 after radiotherapy(p=0.34) , but the proportional percentage of all subpopulations was not changed except CD19(B cell) after irradiation. In the immunoglobulin study, initial values of Ig G, Ig A, and Ig M were relatively above the normal range and the only Ig M was statistically significantly reduced after radiotherapy(p=0.02). Conclusion : Mediastinal and pelvic irradiation resulted in remarkable suppression of lymphocyte count in contrast to the relatively good preservation of other components of white blood cells. But the further study on the functional changes of lymphocyte after radiotherapy may be necessary to conclude the effects of the radiation on the immunity of the cancer Patients.
목적 : 암환자에서 방사선치료에 의한 면역기능의 저하에 대해서는 많은 보고가 되어 있다. 저자들은 방사선치료부위중 비교적 활동성 골수를 많이 포함하고 있는 흥부 및 골반강조사 직후 어느정도 면역력의 저하가 오는지 알아보고자 하였다. 대상 및 방법 : 1995년 1월부터 1995년 4월까지 등록된 61 명의 환자중 48 명을 대상으로 분석 하였다. 이중 흉부(조사문, >