The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Experimental Study of the Effect of Injinsaryungsan and Sosihotang on cholestatic liver injury induced by $ANIT({\alpha}-naphtylisothiocyanate)$

인진사령산(茵陳四岺散)과 소시호탕(小柴胡湯)이 ANIT 로 유발(誘發)된 담즙울체성(膽汁鬱滯性) 간장애(肝障碍)에 미치는 영향(影響)

  • Shin, Sang-Man (Dept. of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Jang-Hun (Dept. of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Woo, Hong-Jung (Dept. of Internal Medicine, College of Oriental Medicine, Kyung Hee University)
  • 신상만 (경희대학교 한의과대학 간계내과학교실) ;
  • 이장훈 (경희대학교 한의과대학 간계내과학교실) ;
  • 우홍정 (경희대학교 한의과대학 간계내과학교실)
  • Published : 1996.10.30
Download PDF
⟨ Previous Next ⟩

Abstract

In an attempt to evaluate the effect of high and low concentration of Injinsaryungsan and high and low concentration of Sosihotang on cholestatic liver injery induced by $ANIT({\alpha}-naphthylisothiocyanate)$, biochemical changes in serum transaminase(GOT, GPT), alkaline phosphate, lactate dehydrogenase, total cholesterol, triglyceride, total-bilirubine were studied and the following results were obtained. 1. High concentration of Injinsaryungsan(2.2g／Kg) inhibited significantly the activity increases of GOT, GPT, ALP, LDH, TC, TG, T-Bilirubine induced by $ANIT({\alpha}-naphthylisothiocyanate)$. 2. Low concentration of Injinsaryungsan(1.1g／Kg) inhibited the activity increases of ALP, LDH, TC, TG with statistical significance, while inhibited the activity increase of GOT ,but with no statistical significance. 3. High concentration of Sosihotang(2.4g／Kg) inhibited the activity increases of LDH, TG, TC with statistical significance while inhibited the activity increases of GOT, GPT, ALP, T-bilirubine with no significance. 4. Low concentration of Sosihotang(1.2g／Kg) inhibited the activity increase of TG, while inhibited the activity increase of ALP, TC with no statistical sig-nificance, but didn't inhibite the activity increases of GOT, GPT, LDH, T-Bil. These results suggest that Injinsaryungsan has more significant effect on the liver injury induced by $ANIT({\alpha}-naphthylisothiocyanate)$ compared with Sosihotang and so can be applicable clinically to virus hepatitis and cholestatic liver injury. Further study will be required to evaluate the effect of Sosibotang on cholangitis and cholecystitis.

Keywords

References

  1. 消化器 疾患 고려의학편집부
  2. 肝系內科學 金秉雲(外)
  3. 新生理學總論 金完熙
  4. 가정의학 서울대출판부
  5. 鄕藥集成方 世宗命(選)
  6. 申氏本草學 申佶求
  7. 現代本草學 安德均
  8. 東醫學方法論 硏究 尹吉榮
  9. 內科學 李文鎬(外)
  10. 本草學 全國韓醫科大學 本草學敎授
  11. 傷寒論譯詮 蔡仁植
  12. 東醫寶鑑 許浚
  13. 精校黃帝內經素問 洪元植
  14. 慶熙大學校 論文集 v.1 茵蔯五笭散의 肝疾患 治療效果에 關한 硏究 金光胡
  15. 동양의학 v.10 急慢性肝疾患에 대한 500명의 臨床效果에 關한 硏究 金秉雲
  16. 東洋醫學 v.22 生肝健脾湯이 肝臟의 代謝와 再生機能에 미치는 影響 金秉雲
  17. 大韓內科學會誌 v.18 韓國人 醫療從事者에 있어서의 肝炎 B형 항원발현빈도 金丁龍
  18. 大韓韓方內科學會誌 v.1 no.1 小柴胡湯 投與가 salmonella typhi標準 細菌에 의하여 發熱된 家兎의 體溫에 미치는 影響에 관한 硏究 盧昇鉉
  19. 慶熙大學校 論文集 茵蔯四笭散이 急性 Alcohol 高脂肪食 및 Galactosamine 中毒白鼠의 肝損傷에 미치는 影響 朴亨圭
  20. 慶熙大學校 論文集 茵蔯蒿湯이 carbon tetrachlolide 中毒으 로 인한 白鼠, 肝臟損傷의 怡療效果에 關한 實驗的 硏究 裵文弘
  21. Medical postgraduate v.15 慢性B型肝炎의 治療 徐東震
  22. 慶熙醫學 v.6 no.2 小柴胡湯에 關한 實驗的 및 臨床的 硏究 禹弘楨
  23. 大韓韓醫學會誌 v.13 茵蔯五笭散과 茵蔯增量한 構成方이 흰쥐 損傷肝에 미치는 影響 禹弘楨
  24. 豫防醫學學會誌 v.21 정상인에 있어서 B型肝炎바이러스 感染에 관한 血淸學的 硏究 유영근
  25. 生肝湯이 CCl4 및 D-galactosamine에 의하여 誘發된 實驗的 흰쥐 肝障碍에 미치는 影響 李昌圭
  26. 慶熙韓醫大論文集 加減小柴胡湯의 解熱 鎭痛 및 損損傷에 미치는 影響 趙鐘寬
  27. 慶熙大學校 論文集 茵蔯五笭散이 CC14中毒으로 因한 白鼠 損傷肝의 治療 效果에 關한 實驗 硏究 趙恒九
  28. 黃帝醫學 v.1 no.2 家兎의 鍼刺出血과 柴胡의 倂用에 따른 解熱效果에 관한 實驗的 硏究 崔容泰
  29. 대한한의학회지 v.15 加味淸肝湯의 效能에 關한 實驗的 硏究 洪尙勳
  30. 醫學正傳 盧天民
  31. 黃帝內經素問$\cdot$靈樞合編 馬時;張誌總(合註)
  32. 千金要方 孫思貌
  33. 大觀本草 愼微選
  34. 醫宗金鑑 吳謙(外)
  35. 黃帝內經 王氷(註)
  36. 外臺秘要 王壽
  37. 醫方集解 旺認庵
  38. 醫學入門 李挺
  39. 景岳全書 張介賓
  40. 金匱要略 張仲景
  41. 仲經全書 張仲景
  42. 漢方醫藥大辭典 陳存仁
  43. 藥學雜誌 v.80 澤瀉의 抗脂肪成分의 分離 小林忠之
  44. 藥學雜誌 v.90 柴胡의 藥理學的 硏究 柴田
  45. 和漢藥物學 高木敬次郎;木村正康;原田正敏;大塚恭男
  46. YAKUGAKU ZASSHI v.111 Protective Effects of Various Methanol Extracts of Crude Drugs on Experimental Hepat ic Injury Induced by $\alpha-Naphthylisothiocyanate$ in Rats Kumazawa, N.;Ohta, S.;Tu, S.H.;Kamogawa, A.;Shinoda, M.
  47. YAKUGAKU ZASSHI v.112 Effects of Various Methanol Extracts of Crude Drugs on Experimental Subacute and Chronic Hepatic Injury Ishizuka, O.;Kumazawa, N.;Ohta, S.;Kamogawa, A.;Shinoda, M.
  48. YAKUGAKU ZASSHI v.113 Protective Effects of Taiwan Crude Drugs on Experimental Liver Injuries Ohta, S.;Sato, N.;Tu, S.H.;Kamokawa, A.;Shinoda, M.
  49. Am. J. Clin. Phathol. v.28 A colorimetric method for the determination of serum glutamic oxaloacetic acid and glutamic pyruvic transaminase Reitman, S.;Frankel, S.
  50. J. Clin. Path. v.7 Estimation plasma phosphatase by determination of hydrolysed phenol with aminoantipyrine Kind, P.R.N.;King, E.J.
  51. Proc. Soc. Exp. Biol. Med. v.90 Lactic dehydrogenase activity in blood Wroblewski, F.;LaDue, J.S.
  52. Clin. Chem. v.20 Enzymatic determation of total cholesterol Allain, C.
  53. Clin. Chem. v.14 The determation of triglycerides in plasma and tissues Sardesa, V.M.;Mannig, J.A.
  54. J. Lab. and Clin. Med. v.50 Micromethod for the determation of serum triglyceride Van Handel, E.;Zilversmit, D.B.
  55. Clin. Chem. v.19 Stan dardization in Bilirubin Assays:Evaluation of Selected Methods and Stability of Bilirubin Solutions Doumas, B.T.;Perry, B.W.;Sasse, E.A.;Strsumfjord, J.V.
  56. YAKUKAGU ZASSHI v.110 Pharmacological Studies on Puerariae Flos.II.The effects of Puerariae Flos on Alcohol-Induced Unusual Metabolism and Experimental Liver Injury in Mice Yujiro, N.;Takashi, Y.;Yoshijiro, N.;Hiroshi, I.;Takashi, T.;Jun-ei, K.;Tochihiro, N.
  57. YAKUGAKU ZASSHI v.102 no.6 Pharmacological studies on Schzandra Fruits. II Maeda, S.;Sudo, K.;Miyamoto, Y.;Takeda, S.;Shinbo, M.;Aburada, M.;Ikeya, Y.;Taguchi, H.;Harada, M.
  58. Chem. Pharm. Bull. v.30 no.9 Protective action of Desoxypodophyllotoxin on D-galactosamine-induced liver lesion in rats Kiso, Y.;Konno, C.;Hikino, H.;Hashimoto, I.;Wakasa, H.
  59. J. Biol. Chem. v.259 Oxygen and Carbon-centered free radical formation during carbon tetrachloride metabolism McCay, P.B.;Lai, E.K.;Poyer, J.L.;DuBose, C.M.;Jansen, E.G.
  60. YAKUGAKU ZASSHI v.104 no.4 Choleretic Activities of Artemisia Plants Okuno, I.;Uchida, K.;Namba, T.
  61. YAKUGAKU ZASSHI v.102 no.3 Biologically Active Principles of Crude Drugs. Pharmacological Evaluation of Artemisiae capillaris Flos(1) Yamamura, J.;Matsuda, H.;Sawada, T.;Mibu, H.;Fujimura, H.
  62. YAKUGAKU ZASSHI v.105 no.6 Antihepatotoxic Activities of Crude Drugs Hikino, H.