The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effect of Ijintang - hot water & methanol extracts - on the regional cerebral blood flow and cerebral edema in MCA occlusioned rats

뇌경색유발(腦梗塞誘發) 흰쥐의 국소뇌혈류량(局所腦血流量)과 뇌부종(腦浮腫)에 대한 이진탕(二陳湯)의 수(水) 및 메탄올추출엑스의 효과(效果)

  • 윤상협 (경희대학교 분당한방병원 내과) ;
  • 민병일 (경희대학교 의과대학 생리학교실) ;
  • 류재환 (경희대학교 동서의학연구소)
  • Published : 1996.10.30
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Abstract

For the purpose of developing a new drug against cerebral infarction, we chose Ijintang which is frequently applied in the field of Jung Pung of traditional medicine. From this formula, water extract and methanol extract were prepared respectively. Animals were divided into three groups; control group, water extract medicated group, methanol extract treated group. water extract was given 195mg／kg orally and methanol extract, 165mg／kg for 2 weeks in case of cerebral edema and 1 month in regional cerebral blood flow. On the regional cerebral blood flow, the drug medicated groups showed no significant changes as compared gith control group. There was no significant difference on the cerebral edema among the groups. According to the results above, it is suggested that oral medication of water extract and methanol extract from Ijintang have no effect on the change of rCBF and edema after acutely induced cerebral infarction. However, it is thought that modification of administration method and development of new animal model for traditional medicine are needed.

Keywords

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