Effects of Saseuptang Water Extracts on the Renal Function in Rats

사습탕(瀉濕湯) 전탕액(煎湯液)이 백서(白鼠)의 신장기능(腎臟機能)에 미치는 영향(影響)

  • Min, Young-Kie (Department of physiology, Wonkwang University, College of Oriental Medicine) ;
  • Yu, Yun-Cho (Department of physiology, Woosuk University, College of Oriental Medicine) ;
  • Lee, Ho-Sub (Department of physiology, Wonkwang University, College of Oriental Medicine) ;
  • Ryu, Do-Gon (Department of physiology, Wonkwang University, College of Oriental Medicine)
  • 민영기 (원광대학교 한의과대학 생리학교실) ;
  • 유윤조 (우석대학교 한의과대학 생리학교실) ;
  • 이호섭 (원광대학교 한의과대학 생리학교실) ;
  • 류도곤 (원광대학교 한의과대학 생리학교실)
  • Published : 1996.04.30

Abstract

The aim of this experiment was to elucidate the effects of Saseuptang water extract on the renal function plasma renin activity and plasma levels of atrial natriuretic peptide and aldosterone in rat The results were as follows; 1. Water balance decreased significantly after the administration of Saseuptang water extract, 0.4 and 0.8ml/kg. 2. Urine volume increased significantly after the administration of Saseuptang water extract, $0.4\;m{\ell}/kg$. 3. Urinary excretion of chloride increased significantly after the administration of Saseupthang water extract, $0.8\;m{\ell}/kg$. 4. Free water clearance increased significantly after the administration of Saseuptang water extract, $0.8\;m{\ell}/kg$. 5. Urinary excretion of creatinine increased significantly after the administration of Saseuptang water extract, $0.8\;m{\ell}/kg$. 6. Plasma levels of atrial natriuretic peptide (ANP) decreased significantly after administration of Saseupthang water extract, $0.8\;m{\ell}/kg$. These results suggest that the changes of urine volume after the administration of Saseuptang water extracts are related to the increments of glomerular filtration rate and free water clearance, and it is suggested that the changes of renal function by which Saseuotang may related to the renin-angiotensin and atrial natriuretic peptide system.

Keywords

References

  1. 丹溪心法附餘 方廣(編);原著 朱震亨
  2. 東醫寶鑑 許浚
  3. 證脈方藥合編 黃度淵
  4. 景岳全書(上) 張介賓
  5. 方藥合編解說 申載鏞
  6. 大韓韓醫學會誌 v.8 腎機能에 對한 東西醫學的 考察 柳道坤(外)
  7. 五苓散煎湯液의 胃內 直接投與가 白鼠의 腎臟機能과 血漿 Renin 活性度 및 Atrial Natriuretic Peptide 濃度에 미치는 影響 金京娥
  8. 導赤散 煎湯液이 家兎의 腎臟機能에 미치는 影響 金仁燮
  9. 五苓散 및 加味五苓散이 家兎 利尿作用에 미치는 影響 李尙仁
  10. 神秘湯 加 木通 煎湯液이 家兎 胃臟機能에 미치는 影響 金明東
  11. In Quantitative Clinical Chemistry Methods v.2 Philips, R.A.;Peter, J.P.(ed.);Vanslyke, D.D.(ed.)
  12. J. Exp. Zool. v.242 Radioimmunoassay and characterization of renin-angioten sin system in the fresh water turtle Cho, K.W.;Kim, S.H.;Koh, G.Y.
  13. Sci. v.144 Antibodies to bradykinin and angiotension, A use of carbodiimide in immunology Goodfriend, T.L.;Levine, L.;Fasman, G.D.
  14. Experimental Am. J. Physiol. v.236 Renin inactivation during in vitro Cho, K.W.;Malvin, R.L.
  15. Am. J. Med v.55 Searching out low renin patients Limitation of some commonly used methods Sealey, J.E.;Laragh, J.H.
  16. Nephron v.51 no.2 Plasma concentration of atrial natriuretic peptide in differente phase of Korean hemmorrhagic fever Cho, K.W.;Kim, S.H.;Koh, G.Y.;Seul, K.H.;Huh, K.S.;Chu, D.;Rapp, S.;Moon, H.B.;Kim, K.K.;Kook, Y.J.
  17. Kor. J. Physiol. v.16 Factors affect in the relationship between renal renin activity and plasma renin activity Cho, K.W.;Kim, S.H.
  18. 素問注釋淮粹 程士德(主編)
  19. 申氏本草學各論 申佶求
  20. 中醫各言大辭典 劉道淸;周一謀
  21. 腎臟學 서울대학교 의과대학
  22. 附子 煎湯液이 家兎의 副腎皮質 및 腎臟機能과 血漿 Renin 活性度에 미치는 影響 柳道坤
  23. 熟地黃 煎湯液과 附子 煎湯液 投與가 白鼠의 腎臟 機能과 血漿 Renin 活性度 및 ANP 濃度에 미치는 影響 魯鎭求
  24. 生理學 成虎慶(外)
  25. 東醫生理學 金完熙(外)
  26. 東醫處方大全 東醫科學院
  27. Acupuncture & Eletro-therapeutics Res. Int. J. v.16 Effects of acupuncture on the plasma atrial natriuretic peptide, aldosterone and renin activity in man Lee, H.S.;Song, J.C.;Kim, K.S.