Journal of Pharmaceutical Investigation
- Volume 26 Issue 4
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- Pages.257-261
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- 1996
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
A Study on the Solubilization and Physical Properties of Sanjoinine-A
산조인 알카로이드의 가용화 및 물성에 관한 연구
- Sheu, Kwang-Gyou (College of Pharmacy, Pusan National University) ;
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Lee, Chi-Ho
(College of Pharmacy, Pusan National University)
- Published : 1996.12.20
Abstract
The seeds of Zizyphus Jujuba have been used as an antianxiety agent for the treatment of insomnia from the earliest times. Sanjoinine-A, isolated from the seeds of Zizyphus Jujuba, have been found to have a minor tranquilizer activity. However this drug is poorly soluble in water. In order to increase the dissolution rate of sanjoinine-A, solid dispersions with PVP-MC and inclusion complex with