Journal of Pharmaceutical Investigation
- 제26권3호
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- Pages.215-219
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- 1996
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
고지혈증 랫트를 이용한 황금, 황련, 대황의 항고지혈 효과
Antihyperlipidemic Activity of Scutellaris baicalensis Georg., Coptidis japonica Makino and Rhei koreanum Nakai on Experimental Hyperlipidemia in Rats
- 노환성 (울산대학교 의과대학) ;
- 고우경 (아산생명과학연구소 민간요법실) ;
- 김운자 (아산생명과학연구소 민간요법실) ;
- 박건구 (아산생명과학연구소 민간요법실) ;
- 조영환 (아산재단 서울중앙병원 약제부) ;
- 박형섭 (울산대학교 의과대학)
- Ro, Hwan-Seong (University of Ulsan, College of Medicine) ;
- Ko, Woo-Kyoung (Asan Institute of Life Science) ;
- Kim, Oon-Ja (Asan Institute of Life Science) ;
- Park, Kun-Koo (Asan Institute of Life Science) ;
- Cho, Young-Whan (Department of Pharmacology, Asan Medical Center) ;
- Park, Hyoung-Sup (University of Ulsan, College of Medicine)
- 발행 : 1996.09.20
초록
Active component was sought among three herb medicines, which are used in combination as a traditional medicine prescribed for patients with hyperlipidemia related diseases. Antihyperlipidemic effect of this remedy has previously been shown model by the authors on the animal model. Hyperlipidemia was induced on male Wistar rats by keeping them on high lipid diet for one week, as previously described by the authors. Blood lipid profile was verified on these rats by measuring total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). Then, the diet was changed to normal. At the same time, methanol extracts of Scutellaris baicalensis Georg.(radix), Coptidis japonica Makino(rhizoma) or Rhei koreanum Nakai(rhizoma) were given on daily basis, and changes in the blood lipid profile were monitored for 4 weeks. Methanol extract of Scutellaris baicalensis Georg. significantly reduced the TC value, implying the in vivo antihyperlipidemic effect.