Journal of Pharmaceutical Investigation
- Volume 26 Issue 3
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- Pages.207-213
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- 1996
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Theoretical Model for the Electrical Resistance of Skin
피부의 전기적 저항에 대한 이론적 모델
- Oh, Seaung-Youl (Biomaterial Laboratory, Korea Research Institute of Chemical Technology)
- 오승열 (한국화학연구소)
- Published : 1996.09.20
Abstract
The kinetic change of electrical resistance of hairless mouse skin as a function of ionic strength of the bathing medium was determined from impedance measurements. After increasing (decreasing) the ionic strength of the bathing medium, resistance decreased (increased) continuously with time, finally reaching an equilibrium value. We have modelled this process, using nonsteady-state diffusion kinetics. The results show semi-quantitative correlation between theoretically derived and experimentally obtained values. Overall, this work provides further mechanistic insight into ion-conduction through the skin.