Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
권호 표지

Effects of Aluminum Compounds on Enzyme Activities in the Serum of Rat

알루미늄 화합물이 흰쥐의 혈청 효소 활성도에 미치는 영향

  • Kim, Joong-Man (College of Life Science and Natural Resources, Wonkwang University) ;
  • Baek, Seung-Hwa (College of Life Science and Natural Resources, Wonkwang University) ;
  • Han, Sung-Hee (College of Life Science and Natural Resources, Wonkwang University) ;
  • Shin, Yong-Seo (College of Life Science and Natural Resources, Wonkwang University) ;
  • Yoon, Tai-Hean (Food Research Institute, Pasteur Milk Co., Ltd.)
  • 김중만 (원광대학교 생명자원과학대학) ;
  • 백승화 (원광대학교 생명자원과학대학) ;
  • 한성희 (원광대학교 생명자원과학대학) ;
  • 신용서 (원광대학교 생명자원과학대학) ;
  • 윤태헌 (파스퇴르유업(주) 식품연구소)
  • Published : 1996.10.30
Download PDF
⟨ Previous Next ⟩

Abstract

This study was performed to investigate the effect of serum enzyme activities in rats after administration of aluminum compound. Seventy five male Sprague-Dawley rats were divided into five groups consisting of control, $250\;ppm\;AlCl_3,\;500\;ppm\;AlCl_3,\;250\;ppm\;Al_2(SO_4)_3$ and $500ppm Al_2(SO_4)_3$ groups and kept on the diet for 2 weeks. The weight gain increased from 0.53 to 3.35% in $AlCl_3$ adiministration groups but decreased from 2.82 to 6.16% in $Al_2(SO_4)_3$, administration groups as compared to control group. As compared to control group, activities of lactate dehydrogenase (LDH) and aspartate amino transaminase (AST) in serum increased 29.43 to 57.68% and 0.68 to 9.97% in $AlCl_3$ adiministration groups, and 74.60 to 29.33% and 21.04 to 24.79% in $Al_2(SO_4)_3$ adiministration groups, respectively. However, alanine amino transminase (ALT) decreased from 12.69 to 25.42% in $AlCl_3$ adiministration groups and from 24.32 to 39.62% in $Al_2(SO_4)_3$ administration groups. Cholinesterase activity increased from 28.98 to 12.73% as compared to control group by administration of $AlCl_3$ and decreased from 3.93 to 14.48% by administration of $Al_2(SO_4)_3$.

알루미늄 화합물이 흰쥐의 효소활성에 미치는 영향을 알아보고자 흰쥐(Sprague-Dawley계 male) 75마리를 5개 그룹 즉, 대조군, $250\;ppm\;AlCl_3\;500\;ppm\;AlCl_3,\;250\;ppm\;Al_2(SO_4)_3,\;500\;ppm\;Al_2(SO_4)_3$로 나누어 2주동안 투여하여 asparate amino transaminase, alanine amino transminase, lactate dehydrogenase, 그리고 cholinesterase의 변화를 조사하였다. 체중은 대조군에 비하여 $Al_2(SO_4)_3$ 투여군은 2.82-6.16% 증가한 반면에 $AlCl_3$ 투여군에서는 0.53-3.35%로 감소하였다. 효소활성은 대조군에 비하여 $AlCl_3$ 또는 $Al_2(SO_4)_3$ 투여후에 AST는 0.68-9.97%, 21.04-24.79%, LDH는 29.43-57.56%, 74.60-29.33% 증가하였으나, ALT는 12.69-25.42%, 24.32-39.62%로 각각 감소하였다. ChE는 대조군에 비하여 $Al_{2}(SO_4)_3$ 투여군은 28.0-12.73% 증가하였으나 $Al_2(SO_4)_3$ 투여군은 3.93-14.48% 감소하였다.

Keywords