Korean Journal of Oriental Medicine (한국한의학연구원논문집)

Korean Institute of Oriental Medicine (한국한의학연구원)
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Effects of Chunggansan on Acute Damages of Liver Induced by Ethanol in Rats

청간산(淸肝散)이 급성(急性) Ethanol 중독(中毒)에 의한 흰쥐의 간손상(肝損傷)에 미치는 영향(影響)

  • Kwak, Ik-Hoon (Dept. of Internal Medicine, College of Oriental Medicine, Dong Guk University) ;
  • Kim, Jong-Dae (Dept. of Internal Medicine, College of Oriental Medicine, Dong Guk University) ;
  • Jeong, Ji- Cheon (Dept. of Internal Medicine, College of Oriental Medicine, Dong Guk University) ;
  • Shin, Uk-Seub (Dept. of Pharmacy, Dongguk medical center)
  • 곽익훈 (동국대학교 한의과대학 내과학교실) ;
  • 김종대 (동국대학교 한의과대학 내과학교실) ;
  • 정지천 (동국대학교 한의과대학 내과학교실) ;
  • 신억섭 (동국의료원 약제과)
  • Published : 1996.12.30
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Abstract

Chunggansan(淸肝散) was tested for the effects on detoxication mechanism of alcohol. Chunggansan was treated firstly into samples, and then ethanol intoxicated animal models were set with them. In vitro, the level of lipid peroxide in tissue of liver proportionally decreased with the level of concentration of extract prepared from Chunggansan. In vivo, after the extract was administered to the animal model for seven days, the level of lipid peroxide in liver dependently decreased in proportion of concentration. The glutathione percentage purposely induced acute ethanol intoxicated samples, followed by Chunggansan pre-medicating administration, increased in compare with the group treated with only ethanol. Also, the enzyme activities of ALT, AST, and ${gamma}-GTP$ in liver decreased.

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