Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Cytotoxicity of Some Natural Products in Human Cancer Cells

수종의 한국산 야생식물에서의 항암효과 검색

  • Park, Sung-Hee (College of Pharmacy, Taegu Hyosung Catholic University) ;
  • Cho, Sung-Ji (College of Pharmacy, Taegu Hyosung Catholic University) ;
  • Rhee, In-Sun (Dept. of Food Science and Technology, Keimyung) ;
  • Lee, Chong-Ock (Pharmaceutical Screening Team, Korea Rearch Institute of Chemical Technology) ;
  • Kim, Chong-Won (College of Pharmacy, Taegu Hyosung Catholic University) ;
  • Rhee, In-Ja (College of Pharmacy, Taegu Hyosung Catholic University)
  • 박성희 (대구효성가톨릭대학교 약학대학) ;
  • 조성지 (대구효성가톨릭대학교 약학대학) ;
  • 이인선 (계명대학교 자연대학) ;
  • 이정옥 (한국화학연구소) ;
  • 김종원 (대구효성가톨릭대학교 약학대학) ;
  • 이인자 (대구효성가톨릭대학교 약학대학)
  • Published : 1996.12.30
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Abstract

The objective of this reseach is to find new antitumoral substances from natural products. Several of natural products have been used as food that were isolated into hexane(Hex.) and/or ethylacetate(EtOAc) extracts. we have tested cytotoxicities of these plants against human solid tumor cells. The cytotoxic activity of these plants were tested using Sulforhodamin B(SRB) assay. Hexane extracts of Chrysanthemum sinense, Allium tubersum. Beta vulgaris, Ixeris dentata have revealed cytotoxicities against five human solid tumor cells, and its cytotoxicities of each cell line were $10-100\;{\mu}l/ml$ ED50 (Effective dose that cause 50% inhibition of cell growth in vitro)

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