생약학회지 (Korean Journal of Pharmacognosy)

  • 제27권4호
  • /
  • Pages.323-327
  • /
  • 1996
  • /
  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

참당귀근 성분이 간의 약물대사효소에 미치는 효과

Effect of the Constituents of Angelicae gigantis Radix on Hepatic Drug Metabolizing Enzymes

  • 한정미 (이화여자대학교 약학대학) ;
  • 이인란 (이화여자대학교 약학대학) ;
  • 신국현 (서울대학교 천연물과학연구소)
  • Han, Jung-Mee (College of Pharmacy, Ewha Woman's University) ;
  • Lee, Ihn-Ran (College of Pharmacy, Ewha Woman's University) ;
  • Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University)
  • 발행 : 1996.12.30
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초록

The ether soluble fraction of the roots of Angelicae gigantis Radix caused a significant prolongation of hexobarbital(HB) induced sleeping time in mice. Through systematic fractionation of the ether fraction monitored by bioassays, two pyranocoumarins, decursinol angelate and decursin were isolated as active principles. Decursin, as a main component, exhibited significant prolongation of HB-induced hypnosis as well as significant inhibition of hepatic microsomal drug metabolizing enzyme(DME) activities at relatively high dose which indicated that it is a weak DME inhibitor.

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