Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effect of G009 on $CCl_4-Induced$ Hepatic Injury and Lipid Peroxidation in Rats

G009가 $CCl_4$로 유발된 간손상 및 지질 과산화에 미치는 영향

  • Jeong, Hoon (Biotechnology Lab., Central Research Institute, Il Yang Pharmaceutical Co. Ltd.) ;
  • Han, Man-Deuk (Biotechnology Lab., Central Research Institute, Il Yang Pharmaceutical Co. Ltd.) ;
  • Baek, Sung-Jin (Biotechnology Lab., Central Research Institute, Il Yang Pharmaceutical Co. Ltd.) ;
  • Kim, Yong-Seok (Biotechnology Lab., Central Research Institute, Il Yang Pharmaceutical Co. Ltd.) ;
  • Kang, Sang-Mo (Department of Microbiological Engineering, College of Engineering, Kon Kuk University) ;
  • Lee, June-Woo (Biotechnology Lab., Central Research Institute, Il Yang Pharmaceutical Co. Ltd.)
  • 정훈 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 한만덕 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 백성진 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 김용석 (일양약품(주) 중앙연구소 생물공학연구실) ;
  • 강상모 (건국대학교 공과대학 미생물공학과) ;
  • 이준우 (일양약품(주) 중앙연구소 생물공학연구실)
  • Published : 1996.09.30
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Abstract

To evaluate hepatoprotective effects of G009, an hepatoprotective agent which was extracted from the mycelia of Ganoderma lucidum IY009, we were, studied using $CCl_4$-and galactosamine-induced hepatotoxicity in rats. The ratio of liver weight to body weight, the value of glutamic oxaloacetic transaminase(GOT) and glutamic pyruvic transaminase (GPT) activities, the change of a lipids in serum, and the inhibitory activity of malondialdehyde (MDA) formation in serum and liver homogenate were determined in rats. G009 was not significantly changed of the ratio of liver weight to body weight and the content of lipids in serum, but reduced the serum GOT and GPT values in $CCl_4$-and galactosamine-induced hepatotoxicity in rat. Especially, protective effect of G009 on rat hepatic injuries induced by galactosamine was significantly appeared. $CCl_4$ increased markedly the formation of lipid peroxides in the liver homogenate, and serum. The increase of lipid peroxides by $CCl_4$-induced hepatotoxicity was markedly reduced by the treatment with G009. These results suggest that the hepatoprotective effects of G009 may be correlated with its anti-lipid peroxidative activity, therefore, it may be potential agent for hepatic disease.

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