Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effect of Solanum lyratum Extract on the Hepatotoxicity of Carbon Tetrachloride in Rats

백모등 엑스의 간기능개선 효과

  • 양재헌 (전주우석대학교 약학대학) ;
  • 최철웅 (전주우석대학교 약학대학) ;
  • 김대근 (전주우석대학교 약학대학) ;
  • 이강노 (성균관대학교 약학대학) ;
  • 지옥표 (성균관대학교 약학대학)
  • Published : 1996.09.30
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Abstract

The studies were attempted to investigate the therapeutic effect of Solanum lyratum extract(SLE) on the liver damage induced by carbon tetrachloride in rats. Male rats (Sprangue-Dawley) were treated with subchronic concentration of $CCl_4$, which was 1 mg/kg of $CCl_4$ via per oral administration daily for three days. The level of serum cholesterol, transaminase, bilirubin and BSP were measured. Treatment of SLE significantly decreased the increment in serum transaminase activities, total cholesterol and enlargement of liver but serum bilirubin was not reduced. The protective effect was observed when SLE was given daily for 4 weeks after $CCl_4$ treated for 3 days. SLE administration to rats prevented the development of fatty change, necrosis, and fibrosis induced by $CCl_4$. The results suggest that SLE has appreciable therapeutic effect on $CCl_4$ induced hepatotoxicity.

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