Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Studies on Development of New Basidiomycetes by Protoplast Fusion and Nuclear Transfer II - The Effects of the Components of the Protoplast Fusants on Mouse Immune Cells -

원형질체 융합 및 핵전이에 의한 새로운 담자균류의 개발에 관한 연구(II) - 융합균사체의 항암성분이 생쥐의 면역세포에 미치는 영향 -

  • Moon, Chul (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) ;
  • Kim, Chae-Kyun (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) ;
  • Yoon, Jong-Myung (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) ;
  • Shim, Mi-Ja (Seoul City University) ;
  • Kim, Ha-Won (Seoul City University) ;
  • Choi, Eung-Chil (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) ;
  • Kim, Byong-Kak (Department of Microbial Chemistry, College of Pharmacy, Seoul National University)
  • 문철 (서울대학교 약학대학 미생물약품화학교실) ;
  • 김채균 (서울대학교 약학대학 미생물약품화학교실) ;
  • 윤종명 (서울대학교 약학대학 미생물약품화학교실) ;
  • 심미자 (서울시립대학교) ;
  • 김하원 (서울시립대학교) ;
  • 최응칠 (서울대학교 약학대학 미생물약품화학교실) ;
  • 김병각 (서울대학교 약학대학 미생물약품화학교실)
  • Published : 1996.09.30
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Abstract

The antitumor components of the protoplast fusants of Lentinula edodes and Ganoderma lucidum were examined for immunological activity to elucidate the mechanism of their antitumor activity. They did not show any direct cytotoxicity against tumor cells. But being examined for immunopotentiation activity, they increased the number of colonies in the bone marrow stem cells to 3.0 times. They also increased the activities of the acid phosphatase in activated macrophages to 2.1 times and the secretion of nitric oxide in RAW 264.7 to 2.2 times, respectively. They activated the components of the alternative complement pathway. In humoral immunity. they increased the activities of the alkaline phosphatase in differentiated B cells to 1.6 times and the number of plaque forming cells to 1.8 times, respectively. In cellular immunity, they restored the depressed response of delayed type hypersensitivity in tumor bearing mice to normal level.

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