Korean Journal of Pharmacognosy (생약학회지)
- Volume 27 Issue 1
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- Pages.20-25
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- 1996
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
In Vitro Anticomplementary Activity of Phenylpropanoids from Agastache rugosa
- Oh, Sei-Ryang (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
- Jung, Keun Young (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
- Lee, Hyeong-Kyu (Korea Research Institute of Bioscience and Biotechnology, KIST)
- Published : 1996.03.30
Abstract
In searching for anticomplementary compounds, three phenylpropanoids were isolated from the roots of Agastache rugosa and identified as rosmarinic acid (RA), rosmarinic acid methyl ester (RAM) and caffeic acid methyl ester (CAM) by NMR analyses. RA and RAM exhibited strong inhibitory activity on both the classical pathway (CP) and the alternative pathway (AP) of the complement system, in vitro, but CAM did far less than RA and RAM.
Keywords
- Agastache rugosa;
- rosmarinic acid;
- rosmarinic acid methyl ester;
- caffeic acid methyl ester;
- anticomplement activity