Natural Product Sciences
- 제2권1호
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- Pages.24-28
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- 1996
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- 1226-3907(pISSN)
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- 2288-9027(eISSN)
Antiinflammatory and Analgesic Effects of Higenamine, a Component of Aconiti Tuber
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Shin, Kuk-Hyun
(Natural Products Research Institute, Seoul National University) ;
- YunChoi, Hye-Sook (College of Pharmacy, Seoul National University) ;
- Chung, Ha-Sook (College of Pharmacy, Seoul National University) ;
- Koo, Kyung-Ah (College of Pharmacy, Seoul National University) ;
- Kim, Deuk-Joon (College of Pharmacy, Seoul National University)
- 발행 : 1996.06.01
초록
The antiinflammatory and analgesic activities of higenamine were evaluated by measuring edema volume and pain threshold in adjuvant arthritic rats and acetic acid-induced writhing test in mice. Higenamine, with consecutive oral administrations at doses of 10 and 50 mg/kg/day, showed significant antiedemic effect and elevation of pain threshold during the secondary lesion of adjuvant arthritis. Higenamine also showed a significant inhibition of acetic acid-induced writhing syndrome with a single oral administration (200 mg/kg). From these results, it is postulated that higenamine might possess both of centrally and peripherally mediated analgesic properties.
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