대한약리학회지 (The Korean Journal of Pharmacology)
- 제32권3호
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- Pages.293-300
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- 1996
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- 0377-9459(pISSN)
Thioacetamide 유발 간성뇌장애에서 뇌파 Power Spectra
Electroencephalogram Power Spectra in Thioacetamide-induced Hepatic Encephalopathy
- 김지희 (경북대학교 의과대학 약리학교실) ;
- 최원진 (경북대학교 의과대학 약리학교실) ;
- 박정숙 (경북대학교 의과대학 약리학교실) ;
- 이향이 (효성카톨릭대학교 약학대학) ;
- 하정희 (영남대학교 의과대학 약리학교실) ;
- 이만기 (경북대학교 의과대학 약리학교실)
- Lee, Chi-Hui (Department of Pharmacology, School of Medicine, Kyungbok National University) ;
- Choi, Won-Jin (Department of Pharmacology, School of Medicine, Kyungbok National University) ;
- Park, Jung-Sook (Department of Pharmacology, School of Medicine, Kyungbok National University) ;
- Lee, Hyang-Yi (College of Pharmacy, Catholic University of Taegu-Hyosung) ;
- Ha, Jeoung-Hee (Department of Pharmacology, School of Medicine, Yeungnam University) ;
- Lee, Maan-Gee (Department of Pharmacology, School of Medicine, Kyungbok National University)
- 발행 : 1996.12.30
초록
흰쥐에 thioacetamide(TAA)를 투여하면 간성뇌장애가 유발된다. 두가지 행동 상태(꼬리 접촉자극 및 미자극)와 세 단계의 신경학적 이상의 단계(정상, 약한 운동실조, 심한 운동실조)별로 뇌파를 기록하였고, 뇌파 스펙트럼 및 대역 분석을 통하여 간성뇌장애 진행동안 뇌파의 정량적인 변동을 관찰하였다. 정상 쥐에서 자극은
During the development of hepatic encephalopathy after thioacetamide (TAA) injection to rat, EEG was recorded at two different states: without or with tactile stimulation of tail at regular intervals. Calculations based on the spectral and band analysis were used. The changes in the power spectra and bands were examined in 3 different behavioral stages: normal, mild ataxia and severe ataxia. In normal rats, the stimulation produced the increase in the power of the theta