The Korean Journal of Physiology
- Volume 30 Issue 1
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- Pages.21-31
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- 1996
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- 0300-4015(pISSN)
Effect of Blood Pressure on the Endothelium-Dependent Contraction in Rat Aorta
- Jeon, Byeong-Hwa (Department of Physiology, College of Medicine, Chungnam National University) ;
- Kim, Hoe-Suk (Department of Physiology, College of Medicine, Chungnam National University) ;
- Kim, Se-Hoon (Department of Physiology, College of Medicine, Chungnam National University) ;
- Chang, Seok-Jong (Department of Physiology, College of Medicine, Chungnam National University)
- Published : 1996.06.30
Abstract
To investigate the mechanisms of increased endothelium-dependent contraction by acetylcholine in hypertensive rats, the relationship between endothelium-dependent contraction by acetylcholine and blood pressure was studied in spontaneously hypertensive rats (SHR), one-kidney, one clip Goldblatt hypertension (1K,1C-GBH) rats, and Wistar-Kyoto rats (WKY). SHR were treated orally with enalapril or nicardipine in order to prevent development of hypertension or suppress the developed hypertension. 1K,1C-GBH rats were made by renal artery stenosis with contralateral nephrectomy in 8 week-WKY. 1. Endothelium-dependent contractions by acetylcholine